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10.1038/s41588-020-00759-x http://scihub22266oqcxt.onion/10.1038/s41588-020-00759-x 33432184!ä!33432184 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2021 ; 53 (2): 205-214 Nephropedia Template TP {{tp|p=33432184|t=2021. A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection |pdf=|usr=}}{{33432184}} gab.com Text A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33432184 #FOAvip Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the cell plasma membrane, resulting in viral RNA genome delivery into the host. Despite ACE2's critical role in SARS-CoV-2 infection, full understanding of ACE2 expression, including in response to viral infection, remains unclear. ACE2 was thought to encode five transcripts and one protein of 805 amino acids. In the present study, we identify a novel short isoform of ACE2 expressed in the airway epithelium, the main site of SARS-CoV-2 infection. Short ACE2 is substantially upregulated in response to interferon stimulation and rhinovirus infection, but not SARS-CoV-2 infection. This short isoform lacks SARS-CoV-2 spike high-affinity binding sites and, altogether, our data are consistent with a model where short ACE2 is unlikely to directly contribute to host susceptibility to SARS-CoV-2 infection. Twit Text FOAVip A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=33432184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33432184 #FOAvip English Wikipedia <ref>{{Cite pmid|33432184}}</ref> A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection #MMPMID33432184 Blume C; Jackson CL; Spalluto CM; Legebeke J; Nazlamova L; Conforti F; Perotin JM; Frank M; Butler J; Crispin M; Coles J; Thompson J; Ridley RA; Dean LSN; Loxham M; Reikine S; Azim A; Tariq K; Johnston DA; Skipp PJ; Djukanovic R; Baralle D; McCormick CJ; Davies DE; Lucas JS; Wheway G; Mennella V Nat Genet 2021[Feb]; 53 (2): 205-214 PMID33432184show ga Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the cell plasma membrane, resulting in viral RNA genome delivery into the host. Despite ACE2's critical role in SARS-CoV-2 infection, full understanding of ACE2 expression, including in response to viral infection, remains unclear. ACE2 was thought to encode five transcripts and one protein of 805 amino acids. In the present study, we identify a novel short isoform of ACE2 expressed in the airway epithelium, the main site of SARS-CoV-2 infection. Short ACE2 is substantially upregulated in response to interferon stimulation and rhinovirus infection, but not SARS-CoV-2 infection. This short isoform lacks SARS-CoV-2 spike high-affinity binding sites and, altogether, our data are consistent with a model where short ACE2 is unlikely to directly contribute to host susceptibility to SARS-CoV-2 infection. |Angiotensin-Converting Enzyme 2/*genetics[MESH] |Animals[MESH] |Binding Sites[MESH] |COVID-19/*genetics[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Epithelial Cells/*metabolism[MESH] |Exons[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Interferons/immunology[MESH] |Protein Binding[MESH] |Protein Isoforms/genetics[MESH] |RNA Splice Sites[MESH] |RNA-Seq[MESH] |Respiratory System/cytology[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Transcriptome[MESH] |Up-Regulation[MESH]A novel ACE2 isoform is expressed in human respiratory epithelia and i(epmc).pdf DeepDyve Pubget Overpricing