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10.1136/gutjnl-2020-323020 http://scihub22266oqcxt.onion/10.1136/gutjnl-2020-323020 33431578!7804842!33431578     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gut 2021 ; 70 (4): 698-706 Nephropedia Template TP {{tp|p=33431578|t=2021. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 |pdf=|usr=}}{{33431578}} gab.com Text Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 JO: Gut http://www.kidney.de/pget.php?&tw=1&pmid=33431578 #FOAvip OBJECTIVE: Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus. METHODS: In this two-hospital cohort study, we obtained blood, stool and patient records from 100 patients with laboratory-confirmed SARS-CoV-2 infection. Serial stool samples were collected from 27 of the 100 patients up to 30 days after clearance of SARS-CoV-2. Gut microbiome compositions were characterised by shotgun sequencing total DNA extracted from stools. Concentrations of inflammatory cytokines and blood markers were measured from plasma. RESULTS: Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals irrespective of whether patients had received medication (p<0.01). Several gut commensals with known immunomodulatory potential such as Faecalibacterium prausnitzii, Eubacterium rectale and bifidobacteria were underrepresented in patients and remained low in samples collected up to 30 days after disease resolution. Moreover, this perturbed composition exhibited stratification with disease severity concordant with elevated concentrations of inflammatory cytokines and blood markers such as C reactive protein, lactate dehydrogenase, aspartate aminotransferase and gamma-glutamyl transferase. CONCLUSION: Associations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent symptoms, highlighting a need to understand how gut microorganisms are involved in inflammation and COVID-19. Twit Text FOAVip Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 ????Gut http://www.kidney.de/pget.php?&tw=1&pmid=33431578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33431578 #FOAvip English Wikipedia <ref>{{Cite pmid|33431578}}</ref> Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 #MMPMID33431578 Yeoh YK; Zuo T; Lui GC; Zhang F; Liu Q; Li AY; Chung AC; Cheung CP; Tso EY; Fung KS; Chan V; Ling L; Joynt G; Hui DS; Chow KM; Ng SSS; Li TC; Ng RW; Yip TC; Wong GL; Chan FK; Wong CK; Chan PK; Ng SC Gut 2021[Apr]; 70 (4): 698-706 PMID33431578show ga OBJECTIVE: Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus. METHODS: In this two-hospital cohort study, we obtained blood, stool and patient records from 100 patients with laboratory-confirmed SARS-CoV-2 infection. Serial stool samples were collected from 27 of the 100 patients up to 30 days after clearance of SARS-CoV-2. Gut microbiome compositions were characterised by shotgun sequencing total DNA extracted from stools. Concentrations of inflammatory cytokines and blood markers were measured from plasma. RESULTS: Gut microbiome composition was significantly altered in patients with COVID-19 compared with non-COVID-19 individuals irrespective of whether patients had received medication (p<0.01). Several gut commensals with known immunomodulatory potential such as Faecalibacterium prausnitzii, Eubacterium rectale and bifidobacteria were underrepresented in patients and remained low in samples collected up to 30 days after disease resolution. Moreover, this perturbed composition exhibited stratification with disease severity concordant with elevated concentrations of inflammatory cytokines and blood markers such as C reactive protein, lactate dehydrogenase, aspartate aminotransferase and gamma-glutamyl transferase. CONCLUSION: Associations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent symptoms, highlighting a need to understand how gut microorganisms are involved in inflammation and COVID-19. |*Bacteria/genetics/immunology/isolation & purification[MESH] |*COVID-19/blood/diagnosis/epidemiology/immunology[MESH] |*Dysbiosis/epidemiology/etiology/immunology/virology[MESH] |*Gastrointestinal Tract/immunology/microbiology/virology[MESH] |*Immunity[MESH] |*SARS-CoV-2/immunology/isolation & purification[MESH] |Adult[MESH] |C-Reactive Protein/analysis[MESH] |Cytokines/analysis[MESH] |DNA, Bacterial/isolation & purification[MESH] |Female[MESH] |Gastrointestinal Microbiome/*immunology[MESH] |Hong Kong[MESH] |Humans[MESH] |Male[MESH] |Severity of Illness Index[MESH]Gut microbiota composition reflects disease severity and dysfunctional(epmc).pdf DeepDyve Pubget Overpricing