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10.3390/cells10010085 http://scihub22266oqcxt.onion/10.3390/cells10010085 33430260!7825711!33430260     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (1): ä Nephropedia Template TP {{tp|p=33430260|t=2021. Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection |pdf=|usr=}}{{33430260}} gab.com Text Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=33430260 #FOAvip Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the diagnostic performance of circulating platelets (PLT)-derived extracellular vesicles (EVs) as biomarkers for Sars-Cov-2 infection, by setting a rapid and reliable test on unmanipulated blood samples. PLT-EVs were quantified by flow cytometry on two independent cohorts of Sars-CoV-2+ (n = 69), Sars-Cov-2- (n = 62) hospitalized patients, and healthy controls. Diagnostic performance of PLT-EVs was evaluated by receiver operating characteristic (ROC) curve. PLT-EVs count were higher in Sars-Cov-2+ compared to Sars-Cov-2- patients or HC. ROC analysis of the combined cohorts showed an AUC = 0.79 and an optimal cut-off value of 1472 EVs/muL, with 75% sensitivity and 74% specificity. These data suggest that PLT-EVs might be an interesting biomarker deserving further investigations to test their predictive power. Twit Text FOAVip Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=33430260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33430260 #FOAvip English Wikipedia <ref>{{Cite pmid|33430260}}</ref> Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection #MMPMID33430260 Cappellano G; Raineri D; Rolla R; Giordano M; Puricelli C; Vilardo B; Manfredi M; Cantaluppi V; Sainaghi PP; Castello L; De Vita N; Scotti L; Vaschetto R; Dianzani U; Chiocchetti A Cells 2021[Jan]; 10 (1): ä PMID33430260show ga Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the diagnostic performance of circulating platelets (PLT)-derived extracellular vesicles (EVs) as biomarkers for Sars-Cov-2 infection, by setting a rapid and reliable test on unmanipulated blood samples. PLT-EVs were quantified by flow cytometry on two independent cohorts of Sars-CoV-2+ (n = 69), Sars-Cov-2- (n = 62) hospitalized patients, and healthy controls. Diagnostic performance of PLT-EVs was evaluated by receiver operating characteristic (ROC) curve. PLT-EVs count were higher in Sars-Cov-2+ compared to Sars-Cov-2- patients or HC. ROC analysis of the combined cohorts showed an AUC = 0.79 and an optimal cut-off value of 1472 EVs/muL, with 75% sensitivity and 74% specificity. These data suggest that PLT-EVs might be an interesting biomarker deserving further investigations to test their predictive power. |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |Blood Platelets/*metabolism/pathology[MESH] |COVID-19/*blood/epidemiology[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Extracellular Vesicles/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of (epmc).pdf DeepDyve Pubget Overpricing