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10.3390/ijms22020559 http://scihub22266oqcxt.onion/10.3390/ijms22020559 33429925!7828090!33429925     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (2): ä Nephropedia Template TP {{tp|p=33429925|t=2021. Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease |pdf=|usr=}}{{33429925}} gab.com Text Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33429925 #FOAvip Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) in response to a variety of stimuli. These NETs are net-like complexes composed of cell-free DNA, histones and neutrophil granule proteins. Besides the evolutionarily conserved mechanism to capture and eliminate pathogens, NETs are also associated with pathophysiological processes of various diseases. Here, we elucidate the mechanisms of NET formation and their different implications in disease. We focused on autoinflammatory and cardiovascular disorders as the leading cause of death. Neutrophil extracellular traps are not only present in various cardiovascular diseases but play an essential role in atherosclerotic plaque formation, arterial and venous thrombosis, as well as in the development and progression of abdominal aortic aneurysms. Furthermore, NETosis can be considered as a source of autoantigens and maintains an inflammatory milieu promoting autoimmune diseases. Indeed, there is further need for research into the balance between NET induction, inhibition, and degradation in order to pharmacologically target NETs and their compounds without impairing the patient's immune defense. This review may be of interest to both basic scientists and clinicians to stimulate translational research and innovative clinical approaches. Twit Text FOAVip Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33429925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33429925 #FOAvip English Wikipedia <ref>{{Cite pmid|33429925}}</ref> Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease #MMPMID33429925 Klopf J; Brostjan C; Eilenberg W; Neumayer C Int J Mol Sci 2021[Jan]; 22 (2): ä PMID33429925show ga Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) in response to a variety of stimuli. These NETs are net-like complexes composed of cell-free DNA, histones and neutrophil granule proteins. Besides the evolutionarily conserved mechanism to capture and eliminate pathogens, NETs are also associated with pathophysiological processes of various diseases. Here, we elucidate the mechanisms of NET formation and their different implications in disease. We focused on autoinflammatory and cardiovascular disorders as the leading cause of death. Neutrophil extracellular traps are not only present in various cardiovascular diseases but play an essential role in atherosclerotic plaque formation, arterial and venous thrombosis, as well as in the development and progression of abdominal aortic aneurysms. Furthermore, NETosis can be considered as a source of autoantigens and maintains an inflammatory milieu promoting autoimmune diseases. Indeed, there is further need for research into the balance between NET induction, inhibition, and degradation in order to pharmacologically target NETs and their compounds without impairing the patient's immune defense. This review may be of interest to both basic scientists and clinicians to stimulate translational research and innovative clinical approaches. |Aortic Aneurysm, Abdominal/pathology[MESH] |Autoimmune Diseases/*immunology/pathology[MESH] |Autoimmunity/immunology[MESH] |COVID-19/immunology/pathology[MESH] |Extracellular Traps/*immunology[MESH] |Humans[MESH] |Neutrophil Activation/immunology[MESH] |Neutrophils/*immunology[MESH] |Plaque, Atherosclerotic/pathology[MESH]Neutrophil Extracellular Traps and Their Implications in Cardiovascula(epmc).pdf DeepDyve Pubget Overpricing