Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41586-020-03148-w http://scihub22266oqcxt.onion/10.1038/s41586-020-03148-w 33429418!7987233!33429418     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 590 (7847): 635-641 Nephropedia Template TP {{tp|p=33429418|t=2021. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia |pdf=|usr=}}{{33429418}} gab.com Text Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=33429418 #FOAvip Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop severe pneumonia and acute respiratory distress syndrome(1) (ARDS). Distinct clinical features in these patients have led to speculation that the immune response to virus in the SARS-CoV-2-infected alveolus differs from that in other types of pneumonia(2). Here we investigate SARS-CoV-2 pathobiology by characterizing the immune response in the alveoli of patients infected with the virus. We collected bronchoalveolar lavage fluid samples from 88 patients with SARS-CoV-2-induced respiratory failure and 211 patients with known or suspected pneumonia from other pathogens, and analysed them using flow cytometry and bulk transcriptomic profiling. We performed single-cell RNA sequencing on 10 bronchoalveolar lavage fluid samples collected from patients with severe coronavirus disease 2019 (COVID-19) within 48 h of intubation. In the majority of patients with SARS-CoV-2 infection, the alveolar space was persistently enriched in T cells and monocytes. Bulk and single-cell transcriptomic profiling suggested that SARS-CoV-2 infects alveolar macrophages, which in turn respond by producing T cell chemoattractants. These T cells produce interferon-gamma to induce inflammatory cytokine release from alveolar macrophages and further promote T cell activation. Collectively, our results suggest that SARS-CoV-2 causes a slowly unfolding, spatially limited alveolitis in which alveolar macrophages containing SARS-CoV-2 and T cells form a positive feedback loop that drives persistent alveolar inflammation. Twit Text FOAVip Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=33429418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33429418 #FOAvip English Wikipedia <ref>{{Cite pmid|33429418}}</ref> Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia #MMPMID33429418 Grant RA; Morales-Nebreda L; Markov NS; Swaminathan S; Querrey M; Guzman ER; Abbott DA; Donnelly HK; Donayre A; Goldberg IA; Klug ZM; Borkowski N; Lu Z; Kihshen H; Politanska Y; Sichizya L; Kang M; Shilatifard A; Qi C; Lomasney JW; Argento AC; Kruser JM; Malsin ES; Pickens CO; Smith SB; Walter JM; Pawlowski AE; Schneider D; Nannapaneni P; Abdala-Valencia H; Bharat A; Gottardi CJ; Budinger GRS; Misharin AV; Singer BD; Wunderink RG Nature 2021[Feb]; 590 (7847): 635-641 PMID33429418show ga Some patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop severe pneumonia and acute respiratory distress syndrome(1) (ARDS). Distinct clinical features in these patients have led to speculation that the immune response to virus in the SARS-CoV-2-infected alveolus differs from that in other types of pneumonia(2). Here we investigate SARS-CoV-2 pathobiology by characterizing the immune response in the alveoli of patients infected with the virus. We collected bronchoalveolar lavage fluid samples from 88 patients with SARS-CoV-2-induced respiratory failure and 211 patients with known or suspected pneumonia from other pathogens, and analysed them using flow cytometry and bulk transcriptomic profiling. We performed single-cell RNA sequencing on 10 bronchoalveolar lavage fluid samples collected from patients with severe coronavirus disease 2019 (COVID-19) within 48 h of intubation. In the majority of patients with SARS-CoV-2 infection, the alveolar space was persistently enriched in T cells and monocytes. Bulk and single-cell transcriptomic profiling suggested that SARS-CoV-2 infects alveolar macrophages, which in turn respond by producing T cell chemoattractants. These T cells produce interferon-gamma to induce inflammatory cytokine release from alveolar macrophages and further promote T cell activation. Collectively, our results suggest that SARS-CoV-2 causes a slowly unfolding, spatially limited alveolitis in which alveolar macrophages containing SARS-CoV-2 and T cells form a positive feedback loop that drives persistent alveolar inflammation. |Bronchoalveolar Lavage Fluid/chemistry/immunology[MESH] |COVID-19/genetics/*immunology/*virology[MESH] |Cohort Studies[MESH] |Humans[MESH] |Interferon-gamma/immunology[MESH] |Interferons/immunology/metabolism[MESH] |Macrophages, Alveolar/*immunology/metabolism/virology[MESH] |Pneumonia, Viral/genetics/*immunology/*virology[MESH] |RNA-Seq[MESH] |SARS-CoV-2/immunology/*pathogenicity[MESH] |Signal Transduction/immunology[MESH] |Single-Cell Analysis[MESH] |T-Lymphocytes/*immunology/metabolism[MESH]Circuits between infected macrophages and T cells in SARS-CoV-2 pneumo(epmc).pdf DeepDyve Pubget Overpricing