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10.1080/10837450.2021.1871918 http://scihub22266oqcxt.onion/10.1080/10837450.2021.1871918 33428504!ä!33428504 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharm+Dev+Technol 2021 ; 26 (3): 328-334 Nephropedia Template TP {{tp|p=33428504|t=2021. Formulation and stability study of hydroxychloroquine sulfate oral suspensions |pdf=|usr=}}{{33428504}} gab.com Text Formulation and stability study of hydroxychloroquine sulfate oral suspensions JO: Pharm Dev Technol http://www.kidney.de/pget.php?&tw=1&pmid=33428504 #FOAvip Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more recently proposed in COVID-19 therapy. Hydroxychloroquine is only available in tablets which are not easy to administer for pediatric and geriatric patients, and patients unable to swallow such as patients found in intensive care units. The aim of this work was to develop and optimize a ready to use liquid hydroxychloroquine formulation and to carry out the corresponding chemical and microbiological stability studies. The formulation was evaluated for ease of preparation, physical properties, and palatability. Its stability was performed at ambient temperature and under refrigeration. After 6 months of stability testing, the results showed no pH change, no drug loss, no microbial development, and no visual change. The formulation, employing excipients in a range that EMA has recommended, showed chemical and microbiological stability for at least 6 months even in the worst storage conditions. Twit Text FOAVip Formulation and stability study of hydroxychloroquine sulfate oral suspensions ????Pharm Dev Technol http://www.kidney.de/pget.php?&tw=1&pmid=33428504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33428504 #FOAvip English Wikipedia <ref>{{Cite pmid|33428504}}</ref> Formulation and stability study of hydroxychloroquine sulfate oral suspensions #MMPMID33428504 El Mershati S; Thouvenin A; Secretan PH; De Lonlay P; Tuchmann-Durand C; Cisternino S; Schlatter J Pharm Dev Technol 2021[Mar]; 26 (3): 328-334 PMID33428504show ga Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more recently proposed in COVID-19 therapy. Hydroxychloroquine is only available in tablets which are not easy to administer for pediatric and geriatric patients, and patients unable to swallow such as patients found in intensive care units. The aim of this work was to develop and optimize a ready to use liquid hydroxychloroquine formulation and to carry out the corresponding chemical and microbiological stability studies. The formulation was evaluated for ease of preparation, physical properties, and palatability. Its stability was performed at ambient temperature and under refrigeration. After 6 months of stability testing, the results showed no pH change, no drug loss, no microbial development, and no visual change. The formulation, employing excipients in a range that EMA has recommended, showed chemical and microbiological stability for at least 6 months even in the worst storage conditions. |*COVID-19 Drug Treatment[MESH] |Antimalarials/*chemistry[MESH] |Chromatography, High Pressure Liquid[MESH] |Drug Compounding[MESH] |Drug Contamination/prevention & control[MESH] |Drug Stability[MESH] |Humans[MESH] |Hydroxychloroquine/*chemistry[MESH] |Quality Control[MESH] |Suspensions[MESH]Formulation and stability study of hydroxychloroquine sulfate oral sus(epmc).pdf DeepDyve Pubget Overpricing