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10.1172/JCI145476 http://scihub22266oqcxt.onion/10.1172/JCI145476 33427749!7919723!33427749     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (5): ä Nephropedia Template TP {{tp|p=33427749|t=2021. SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals |pdf=|usr=}}{{33427749}} gab.com Text SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33427749 #FOAvip Characterization of the T cell response in individuals who recover from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-sectional sample of 30 coronavirus disease 2019 convalescent individuals. T cells were evaluated using a 28-marker phenotypic panel, and findings were modelled against time from diagnosis and from humoral and inflammatory responses. There were 132 SARS-CoV-2-specific CD8+ T cell responses detected across 6 different HLAs, corresponding to 52 unique epitope reactivities. CD8+ T cell responses were detected in almost all convalescent individuals and were directed against several structural and nonstructural target epitopes from the entire SARS-CoV-2 proteome. A unique phenotype for SARS-CoV-2-specific T cells was observed that was distinct from other common virus-specific T cells detected in the same cross-sectional sample and characterized by early differentiation kinetics. Modelling demonstrated a coordinated and dynamic immune response characterized by a decrease in inflammation, increase in neutralizing antibody titer, and differentiation of a specific CD8+ T cell response. Overall, T cells exhibited distinct differentiation into stem cell and transitional memory states (subsets), which may be key to developing durable protection. Twit Text FOAVip SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33427749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33427749 #FOAvip English Wikipedia <ref>{{Cite pmid|33427749}}</ref> SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals #MMPMID33427749 Kared H; Redd AD; Bloch EM; Bonny TS; Sumatoh H; Kairi F; Carbajo D; Abel B; Newell EW; Bettinotti MP; Benner SE; Patel EU; Littlefield K; Laeyendecker O; Shoham S; Sullivan D; Casadevall A; Pekosz A; Nardin A; Fehlings M; Tobian AA; Quinn TC J Clin Invest 2021[Mar]; 131 (5): ä PMID33427749show ga Characterization of the T cell response in individuals who recover from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-sectional sample of 30 coronavirus disease 2019 convalescent individuals. T cells were evaluated using a 28-marker phenotypic panel, and findings were modelled against time from diagnosis and from humoral and inflammatory responses. There were 132 SARS-CoV-2-specific CD8+ T cell responses detected across 6 different HLAs, corresponding to 52 unique epitope reactivities. CD8+ T cell responses were detected in almost all convalescent individuals and were directed against several structural and nonstructural target epitopes from the entire SARS-CoV-2 proteome. A unique phenotype for SARS-CoV-2-specific T cells was observed that was distinct from other common virus-specific T cells detected in the same cross-sectional sample and characterized by early differentiation kinetics. Modelling demonstrated a coordinated and dynamic immune response characterized by a decrease in inflammation, increase in neutralizing antibody titer, and differentiation of a specific CD8+ T cell response. Overall, T cells exhibited distinct differentiation into stem cell and transitional memory states (subsets), which may be key to developing durable protection. |*Convalescence[MESH] |*Models, Immunological[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |COVID-19/*immunology/pathology[MESH] |Female[MESH] |HLA Antigens/immunology[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 ind(epmc).pdf DeepDyve Pubget Overpricing