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10.1021/acs.analchem.0c04049 http://scihub22266oqcxt.onion/10.1021/acs.analchem.0c04049 33427452!ä!33427452 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anal+Chem 2021 ; 93 (4): 2191-2199 Nephropedia Template TP {{tp|p=33427452|t=2021. Fast Screening and Primary Diagnosis of COVID-19 by ATR-FT-IR |pdf=|usr=}}{{33427452}} gab.com Text Fast Screening and Primary Diagnosis of COVID-19 by ATR-FT-IR JO: Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=33427452 #FOAvip The outbreak of coronavirus disease 2019 (COVID-19) has led to substantial infections and mortality around the world. Fast screening and diagnosis are thus crucial for quick isolation and clinical intervention. In this work, we showed that attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FT-IR) can be a primary diagnostic tool for COVID-19 as a supplement to in-use techniques. It requires only a small volume ( approximately 3 muL) of the serum sample and a shorter detection time (several minutes). The distinct spectral differences and the separability between normal control and COVID-19 were investigated using multivariate and statistical analysis. Results showed that ATR-FT-IR coupled with partial least squares discriminant analysis was effective to differentiate COVID-19 from normal controls and some common respiratory viral infections or inflammation, with the area under the receiver operating characteristic curve (AUROC) of 0.9561 (95% CI: 0.9071-0.9774). Several serum constituents including, but not just, antibodies and serum phospholipids could be reflected on the infrared spectra, serving as "chemical fingerprints" and accounting for good model performances. Twit Text FOAVip Fast Screening and Primary Diagnosis of COVID-19 by ATR-FT-IR ????Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=33427452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33427452 #FOAvip English Wikipedia <ref>{{Cite pmid|33427452}}</ref> Fast Screening and Primary Diagnosis of COVID-19 by ATR-FT-IR #MMPMID33427452 Zhang L; Xiao M; Wang Y; Peng S; Chen Y; Zhang D; Zhang D; Guo Y; Wang X; Luo H; Zhou Q; Xu Y Anal Chem 2021[Feb]; 93 (4): 2191-2199 PMID33427452show ga The outbreak of coronavirus disease 2019 (COVID-19) has led to substantial infections and mortality around the world. Fast screening and diagnosis are thus crucial for quick isolation and clinical intervention. In this work, we showed that attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FT-IR) can be a primary diagnostic tool for COVID-19 as a supplement to in-use techniques. It requires only a small volume ( approximately 3 muL) of the serum sample and a shorter detection time (several minutes). The distinct spectral differences and the separability between normal control and COVID-19 were investigated using multivariate and statistical analysis. Results showed that ATR-FT-IR coupled with partial least squares discriminant analysis was effective to differentiate COVID-19 from normal controls and some common respiratory viral infections or inflammation, with the area under the receiver operating characteristic curve (AUROC) of 0.9561 (95% CI: 0.9071-0.9774). Several serum constituents including, but not just, antibodies and serum phospholipids could be reflected on the infrared spectra, serving as "chemical fingerprints" and accounting for good model performances. |COVID-19/*diagnosis[MESH] |Case-Control Studies[MESH] |Diagnosis, Differential[MESH] |Discriminant Analysis[MESH] |Feasibility Studies[MESH] |Humans[MESH]Fast Screening and Primary Diagnosis of COVID-19 by ATR-FT-IR (epmc).pdf DeepDyve Pubget Overpricing