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10.1002/jmv.26789

http://scihub22266oqcxt.onion/10.1002/jmv.26789
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33427302!8014628!33427302
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suck abstract from ncbi


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pmid33427302      J+Med+Virol 2021 ; 93 (4): 2548-2552
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  • Antibody response to SARS-CoV-2 in infected patients with different clinical outcome #MMPMID33427302
  • Anichini G; Gandolfo C; Terrosi C; Fabrizi S; Miceli GB; Gori Savellini G; Prathyumnan S; Franchi F; Cusi MG
  • J Med Virol 2021[Apr]; 93 (4): 2548-2552 PMID33427302show ga
  • Data regarding antibody responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in patients infected with COVID-19 are not yet available. In this study, we aimed to evaluate serum antibody responses in patients regardless of the outcome. We measured the circulating immunoglobulin G (IgG) antibody levels in 60 subjects with a certified history of SARS-CoV-2 infection by using immunoenzymatic, chemiluminescent, and Neutralization assays. Half patients had a severe infection, the other half were pauci-symptomatic. We analyzed their antibody response to see the trend of the humoral response. Our results showed a significant difference in circulating IgG level among the two groups. The neutralizing antibody response against SARS-CoV-2 was significantly higher among those who had severe disease. Furthermore, ten subjects from each group were screened twice, and a declining antibody trend was observed in pauci-symptomatic individuals. These findings provide evidence that humoral immunity against SARS-CoV-2 in pauci-symptomatic people is weak and may not be long-lasting. This may have implications for immunity strategy and prevention, since it is still not clear whether a time-dependent decrease of both circulating and neutralizing antibodies to nonprotective levels could occur in a longer time span and whether potential vaccines are able to induce a herd immunity and a durable response.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/blood[MESH]
  • |Antibodies, Viral/*biosynthesis/*blood[MESH]
  • |Antibody Formation[MESH]
  • |COVID-19/immunology/*virology[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Humans[MESH]
  • |Immunity, Humoral[MESH]
  • |Immunoglobulin G/blood/isolation & purification[MESH]
  • |Middle Aged[MESH]
  • |Neutralization Tests[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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