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10.1017/S095026882100008X

http://scihub22266oqcxt.onion/10.1017/S095026882100008X
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33427152!7847743!33427152
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suck abstract from ncbi


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pmid33427152      Epidemiol+Infect 2021 ; 149 (ä): e18
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  • SARS-CoV-2 viral RNA load dynamics in the nasopharynx of infected children #MMPMID33427152
  • Kam KQ; Thoon KC; Maiwald M; Chong CY; Soong HY; Loo LH; Tan NWH; Li J; Nadua KD; Yung CF
  • Epidemiol Infect 2021[Jan]; 149 (ä): e18 PMID33427152show ga
  • It is important to understand the temporal trend of the paediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load to estimate the transmission potential of children in schools and communities. We determined the differences in SARS-CoV-2 viral load dynamics between nasopharyngeal samples of infected asymptomatic and symptomatic children. Serial cycle threshold values of SARS-CoV-2 from the nasopharynx of a cohort of infected children were collected for analysis. Among 17 infected children, 10 (58.8%) were symptomatic. Symptomatic children, when compared to asymptomatic children, had higher viral loads (mean cycle threshold on day 7 of illness 28.6 vs. 36.7, P = 0.02). Peak SARS-CoV-2 viral loads occurred around day 2 of illness in infected children. Although we were unable to directly demonstrate infectivity, the detection of significant amount of virus in the upper airway of asymptomatic children suggest that they have the potential to shed and transmit SARS-CoV-2. Our study highlights the importance of contact tracing and screening for SARS-CoV-2 in children with epidemiological risk factors regardless of their symptom status, in order to improve containment of the virus in the community, including educational settings.
  • |*Viral Load[MESH]
  • |Adolescent[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Nasopharynx/*virology[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |RNA, Viral/*analysis[MESH]


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