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10.4103/japtr.JAPTR_84_20 http://scihub22266oqcxt.onion/10.4103/japtr.JAPTR_84_20 33425697!7784943!33425697     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Adv+Pharm+Technol+Res 2020 ; 11 (4): 157-162 Nephropedia Template TP {{tp|p=33425697|t=2020. The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm f) Ness |pdf=|usr=}}{{33425697}} gab.com Text The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm f) Ness JO: J Adv Pharm Technol Res http://www.kidney.de/pget.php?&tw=1&pmid=33425697 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. Andrographis paniculata (Burm. f) Ness (AP) is naturally used to treat various diseases, including infectious diseases. Its Andrographolide has been clinically observed for anti-HIV and has also in silico tested for COVID-19 main protease inhibitors. Meanwhile, the AP phytochemicals content also provides insight into the molecular structures diversity for the bioactive discovery. This study aims to find COVID-19 main protease inhibitor from AP by the molecular docking method and determine the toxicity profile of the compounds. The results obtained two compounds consisting of flavonoid glycosides 5,4'-dihydroxy-7-O-beta -D-pyran-glycuronate butyl ester and andrographolide glycoside 3-O-beta-D-glucopyranosyl-andrographolide have lower free binding energy and highest similarity in types of interaction with amino acid residues compared to its co-crystal ligands (6LU7) and Indinavir or Remdesivir. The toxicity prediction of the compounds also reveals their safety. These results confirm the probability of using AP phytochemical compounds as COVID-19 main protease inhibitors, although further research must be carried out. Twit Text FOAVip The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm f) Ness ????J Adv Pharm Technol Res http://www.kidney.de/pget.php?&tw=1&pmid=33425697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33425697 #FOAvip English Wikipedia <ref>{{Cite pmid|33425697}}</ref> The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm f) Ness #MMPMID33425697 Sukardiman; Ervina M; Fadhil Pratama MR; Poerwono H; Siswodihardjo S J Adv Pharm Technol Res 2020[Oct]; 11 (4): 157-162 PMID33425697show ga The coronavirus disease 2019 (COVID-19) pandemic has attracted worldwide attention. Andrographis paniculata (Burm. f) Ness (AP) is naturally used to treat various diseases, including infectious diseases. Its Andrographolide has been clinically observed for anti-HIV and has also in silico tested for COVID-19 main protease inhibitors. Meanwhile, the AP phytochemicals content also provides insight into the molecular structures diversity for the bioactive discovery. This study aims to find COVID-19 main protease inhibitor from AP by the molecular docking method and determine the toxicity profile of the compounds. The results obtained two compounds consisting of flavonoid glycosides 5,4'-dihydroxy-7-O-beta -D-pyran-glycuronate butyl ester and andrographolide glycoside 3-O-beta-D-glucopyranosyl-andrographolide have lower free binding energy and highest similarity in types of interaction with amino acid residues compared to its co-crystal ligands (6LU7) and Indinavir or Remdesivir. The toxicity prediction of the compounds also reveals their safety. These results confirm the probability of using AP phytochemical compounds as COVID-19 main protease inhibitors, although further research must be carried out. äThe coronavirus disease 2019 main protease inhibitor from Andrographis(epmc).pdf DeepDyve Pubget Overpricing