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10.1016/j.csbj.2020.12.016 http://scihub22266oqcxt.onion/10.1016/j.csbj.2020.12.016 33425248!7773686!33425248     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Struct+Biotechnol+J 2021 ; 19 (ä): 153-160 Nephropedia Template TP {{tp|p=33425248|t=2021. Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes |pdf=|usr=}}{{33425248}} gab.com Text Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes JO: Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=33425248 #FOAvip Characterizing key molecular and cellular pathways involved in COVID-19 is essential for disease prognosis and management. We perform shotgun transcriptome sequencing of human RNA obtained from nasopharyngeal swabs of patients with COVID-19, and identify a molecular signature associated with disease severity. Specifically, we identify globally dysregulated immune related pathways, such as cytokine-cytokine receptor signaling, complement and coagulation cascades, JAK-STAT, and TGF- beta signaling pathways in all, though to a higher extent in patients with severe symptoms. The excessive release of cytokines and chemokines such as CCL2, CCL22, CXCL9 and CXCL12 and certain interferons and interleukins related genes like IFIH1, IFI44, IFIT1 and IL10 were significantly higher in patients with severe clinical presentation compared to mild and moderate presentations. Differential gene expression analysis identified a small set of regulatory genes that might act as strong predictors of patient outcome. Our data suggest that rapid transcriptome analysis of nasopharyngeal swabs can be a powerful approach to quantify host molecular response and may provide valuable insights into COVID-19 pathophysiology. Twit Text FOAVip Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes ????Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=33425248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33425248 #FOAvip English Wikipedia <ref>{{Cite pmid|33425248}}</ref> Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes #MMPMID33425248 Jain R; Ramaswamy S; Harilal D; Uddin M; Loney T; Nowotny N; Alsuwaidi H; Varghese R; Deesi Z; Alkhajeh A; Khansaheb H; Alsheikh-Ali A; Abou Tayoun A Comput Struct Biotechnol J 2021[]; 19 (ä): 153-160 PMID33425248show ga Characterizing key molecular and cellular pathways involved in COVID-19 is essential for disease prognosis and management. We perform shotgun transcriptome sequencing of human RNA obtained from nasopharyngeal swabs of patients with COVID-19, and identify a molecular signature associated with disease severity. Specifically, we identify globally dysregulated immune related pathways, such as cytokine-cytokine receptor signaling, complement and coagulation cascades, JAK-STAT, and TGF- beta signaling pathways in all, though to a higher extent in patients with severe symptoms. The excessive release of cytokines and chemokines such as CCL2, CCL22, CXCL9 and CXCL12 and certain interferons and interleukins related genes like IFIH1, IFI44, IFIT1 and IL10 were significantly higher in patients with severe clinical presentation compared to mild and moderate presentations. Differential gene expression analysis identified a small set of regulatory genes that might act as strong predictors of patient outcome. Our data suggest that rapid transcriptome analysis of nasopharyngeal swabs can be a powerful approach to quantify host molecular response and may provide valuable insights into COVID-19 pathophysiology. äHost transcriptomic profiling of COVID-19 patients with mild, moderate(epmc).pdf DeepDyve Pubget Overpricing