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10.1080/17512433.2021.1874348 http://scihub22266oqcxt.onion/10.1080/17512433.2021.1874348 33423554!ä!33423554 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Rev+Clin+Pharmacol 2021 ; 14 (2): 225-238 Nephropedia Template TP {{tp|p=33423554|t=2021. SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development |pdf=|usr=}}{{33423554}} gab.com Text SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development JO: Expert Rev Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33423554 #FOAvip Introduction: Protein drug targets play a significant choice in different stages of the drug discovery process. There is an urgent need to understand the drug discovery approaches and protein drug targets (PDT) of SARS-CoV-2, with structural insights for the development of SARS-CoV-2 drugs through targeted therapeutic approach.Areas covered: We have described the protein as a drug target class and also discussed various drug discovery approaches for SARS-CoV-2 involving the protein drug targets such as drug repurposing study, designing of viral entry inhibitors, viral replication inhibitors, and different enzymes of the virus. We have performed comprehensive literature search from the popular databases such as PubMed Google scholar, Web of Science, and Scopus. Finally, we have illustrated the structural landscape of different significant viral proteins (3 CLpro or Mpro, PLpro, RdRp, helicase, S protein) and host proteins as drug targets (cathepsin L, furin, TMPRSS2, ACE2).Expert opinion: The structural landscape of PDT with their binding pockets, and significant residues involved in binding has been discussed further to better understand the PDT and the structure-based drug discovery for SARS-CoV-2. This attempt will increase more therapeutic options, and combination therapies with a multi-target strategy. Twit Text FOAVip SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development ????Expert Rev Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33423554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33423554 #FOAvip English Wikipedia <ref>{{Cite pmid|33423554}}</ref> SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development #MMPMID33423554 Chakraborty C; Bhattacharya M; Mallick B; Sharma AR; Lee SS; Agoramoorthy G Expert Rev Clin Pharmacol 2021[Feb]; 14 (2): 225-238 PMID33423554show ga Introduction: Protein drug targets play a significant choice in different stages of the drug discovery process. There is an urgent need to understand the drug discovery approaches and protein drug targets (PDT) of SARS-CoV-2, with structural insights for the development of SARS-CoV-2 drugs through targeted therapeutic approach.Areas covered: We have described the protein as a drug target class and also discussed various drug discovery approaches for SARS-CoV-2 involving the protein drug targets such as drug repurposing study, designing of viral entry inhibitors, viral replication inhibitors, and different enzymes of the virus. We have performed comprehensive literature search from the popular databases such as PubMed Google scholar, Web of Science, and Scopus. Finally, we have illustrated the structural landscape of different significant viral proteins (3 CLpro or Mpro, PLpro, RdRp, helicase, S protein) and host proteins as drug targets (cathepsin L, furin, TMPRSS2, ACE2).Expert opinion: The structural landscape of PDT with their binding pockets, and significant residues involved in binding has been discussed further to better understand the PDT and the structure-based drug discovery for SARS-CoV-2. This attempt will increase more therapeutic options, and combination therapies with a multi-target strategy. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/*virology[MESH] |Drug Delivery Systems[MESH] |Drug Development[MESH] |Drug Repositioning[MESH] |Humans[MESH] |SARS-CoV-2/*drug effects[MESH]SARS-CoV-2 protein drug targets landscape: a potential pharmacological(epmc).pdf DeepDyve Pubget Overpricing