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10.1093/bib/bbaa387 http://scihub22266oqcxt.onion/10.1093/bib/bbaa387 33423067!7929461!33423067     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33423067.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Brief+Bioinform 2021 ; 22 (2): 1378-1386 Nephropedia Template TP {{tp|p=33423067|t=2021. Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus |pdf=|usr=}}{{33423067}} gab.com Text Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33423067 #FOAvip Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are urgently required. We studied an already-approved botanical drug cepharanthine (CEP) in a cell culture model of GX_P2V, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related virus. RNA-sequencing results showed the virus perturbed the expression of multiple genes including those associated with cellular stress responses such as endoplasmic reticulum (ER) stress and heat shock factor 1 (HSF1)-mediated heat shock response, of which heat shock response-related genes and pathways were at the core. CEP was potent to reverse most dysregulated genes and pathways in infected cells including ER stress/unfolded protein response and HSF1-mediated heat shock response. Additionally, single-cell transcriptomes also confirmed that genes of cellular stress responses and autophagy pathways were enriched in several peripheral blood mononuclear cells populations from COVID-19 patients. In summary, this study uncovered the transcriptome of a SARS-CoV-2-related coronavirus infection model and anti-viral activities of CEP, providing evidence for CEP as a promising therapeutic option for SARS-CoV-2 infection. Twit Text FOAVip Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33423067 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33423067 #FOAvip English Wikipedia <ref>{{Cite pmid|33423067}}</ref> Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus #MMPMID33423067 Li S; Liu W; Chen Y; Wang L; An W; An X; Song L; Tong Y; Fan H; Lu C Brief Bioinform 2021[Mar]; 22 (2): 1378-1386 PMID33423067show ga Antiviral therapies targeting the pandemic coronavirus disease 2019 (COVID-19) are urgently required. We studied an already-approved botanical drug cepharanthine (CEP) in a cell culture model of GX_P2V, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related virus. RNA-sequencing results showed the virus perturbed the expression of multiple genes including those associated with cellular stress responses such as endoplasmic reticulum (ER) stress and heat shock factor 1 (HSF1)-mediated heat shock response, of which heat shock response-related genes and pathways were at the core. CEP was potent to reverse most dysregulated genes and pathways in infected cells including ER stress/unfolded protein response and HSF1-mediated heat shock response. Additionally, single-cell transcriptomes also confirmed that genes of cellular stress responses and autophagy pathways were enriched in several peripheral blood mononuclear cells populations from COVID-19 patients. In summary, this study uncovered the transcriptome of a SARS-CoV-2-related coronavirus infection model and anti-viral activities of CEP, providing evidence for CEP as a promising therapeutic option for SARS-CoV-2 infection. |*Transcriptome[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Benzylisoquinolines/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |Homeostasis[MESH] |Humans[MESH] |SARS-CoV-2/*drug effects[MESH]Transcriptome analysis of cepharanthine against a SARS-CoV-2-related c(epmc).pdf DeepDyve Pubget Overpricing