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10.1016/j.ebiom.2020.103197

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33422991!7808923!33422991
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suck abstract from ncbi


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pmid33422991      EBioMedicine 2021 ; 63 (ä): 103197
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  • Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice #MMPMID33422991
  • Worzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Karlsson Hedestam GB; Murrell B; Christensen D; Pedersen GK
  • EBioMedicine 2021[Jan]; 63 (ä): 103197 PMID33422991show ga
  • BACKGROUND: SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority. Subunit vaccines are used successfully against other viruses when administered in the presence of an effective adjuvant. METHODS: We evaluated three different clinically tested adjuvant systems in combination with the SARS-CoV-2 pre-fusion stabilized (S-2P) spike protein using a one-dose regimen in mice. FINDINGS: Whilst spike protein alone was only weakly immunogenic, the addition of either Aluminum hydroxide, a squalene based oil-in-water emulsion system (SE) or a cationic liposome-based adjuvant significantly enhanced antibody responses against the spike receptor binding domain (RBD). Kinetics of antibody responses differed, with SE providing the most rapid response. Neutralizing antibodies developed after a single immunization in all adjuvanted groups with ID(50) titers ranging from 86-4063. Spike-specific CD4 T helper responses were also elicited, comprising mainly of IFN-gamma and IL-17 producing cells in the cationic liposome adjuvanted group, and more IL-5- and IL-10-secreting cells in the AH group. INTERPRETATION: These results demonstrate that adjuvanted spike protein subunit vaccine is a viable strategy for rapidly eliciting SARS-CoV-2 neutralizing antibodies and CD4 T cell responses of various qualities depending on the adjuvant used, which can be explored in further vaccine development against COVID-19. FUNDING: This work was supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.
  • |Adjuvants, Immunologic/administration & dosage/chemistry[MESH]
  • |Aluminum Hydroxide/chemistry[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/immunology/*metabolism[MESH]
  • |Antibodies, Viral/immunology/*metabolism[MESH]
  • |CD4-Positive T-Lymphocytes/cytology/*immunology/metabolism[MESH]
  • |COVID-19/pathology/virology[MESH]
  • |Female[MESH]
  • |Immunization[MESH]
  • |Interferon-gamma/metabolism[MESH]
  • |Interleukin-17/metabolism[MESH]
  • |Liposomes/chemistry[MESH]
  • |Mice[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |SARS-CoV-2/isolation & purification/*metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/*immunology[MESH]
  • |Squalene/chemistry[MESH]


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