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10.1016/j.mehy.2020.110415 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110415 33422363!7685948!33422363     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2021 ; 146 (ä): 110415 Nephropedia Template TP {{tp|p=33422363|t=2021. Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3 UTR of pro-inflammatory mRNAs |pdf=|usr=}}{{33422363}} gab.com Text Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3 UTR of pro-inflammatory mRNAs JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33422363 #FOAvip COVID-19 is characterized by two major clinical phases, the SARS-CoV-2 infection of target cells and tissues, and a deep inflammatory state, known as "cytokine storm", caused by activation of pro-inflammatory genes, such as NF-kB, STAT-3, IL-6, IL-8, IL-1ss. Among possible anti-inflammatory agents, the "microRNA targeting" should be carefully considered, since it is well known that microRNAs are deeply involved in the expression of cytokines, chemokines and growth factors. The working general hypothesis is that targeting the microRNA network might be important for the development of therapeutic approaches to counteract the COVID-19 induction of inflammatory response. This hypothesis is based on several publications demonstrating the use of miRNA mimics for inhibitory effects on the production of proteins characterizing the COVID-19 "cytokine storm". Twit Text FOAVip Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3 UTR of pro-inflammatory mRNAs ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33422363 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33422363 #FOAvip English Wikipedia <ref>{{Cite pmid|33422363}}</ref> Tackling the COVID-19 "cytokine storm" with microRNA mimics directly targeting the 3 UTR of pro-inflammatory mRNAs #MMPMID33422363 Gasparello J; Finotti A; Gambari R Med Hypotheses 2021[Jan]; 146 (ä): 110415 PMID33422363show ga COVID-19 is characterized by two major clinical phases, the SARS-CoV-2 infection of target cells and tissues, and a deep inflammatory state, known as "cytokine storm", caused by activation of pro-inflammatory genes, such as NF-kB, STAT-3, IL-6, IL-8, IL-1ss. Among possible anti-inflammatory agents, the "microRNA targeting" should be carefully considered, since it is well known that microRNAs are deeply involved in the expression of cytokines, chemokines and growth factors. The working general hypothesis is that targeting the microRNA network might be important for the development of therapeutic approaches to counteract the COVID-19 induction of inflammatory response. This hypothesis is based on several publications demonstrating the use of miRNA mimics for inhibitory effects on the production of proteins characterizing the COVID-19 "cytokine storm". |*Models, Biological[MESH] |3' Untranslated Regions/genetics[MESH] |Anti-Inflammatory Agents/pharmacology[MESH] |COVID-19/genetics/immunology/*therapy[MESH] |Cytokine Release Syndrome/genetics/immunology/*therapy[MESH] |Humans[MESH] |Inflammation/genetics/immunology/therapy[MESH] |MicroRNAs/*genetics/therapeutic use[MESH] |Molecular Mimicry[MESH] |RNA, Messenger/antagonists & inhibitors/genetics[MESH]Tackling the COVID-19 "cytokine storm" with microRNA mimics directly t(epmc).pdf DeepDyve Pubget Overpricing