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10.1016/j.metabol.2021.154703 http://scihub22266oqcxt.onion/10.1016/j.metabol.2021.154703 33421506!7834365!33421506     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Metabolism 2021 ; 117 (ä): 154703 Nephropedia Template TP {{tp|p=33421506|t=2021. Excess body weight is an independent risk factor for severe forms of COVID-19 |pdf=|usr=}}{{33421506}} gab.com Text Excess body weight is an independent risk factor for severe forms of COVID-19 JO: Metabolism http://www.kidney.de/pget.php?&tw=1&pmid=33421506 #FOAvip BACKGROUND AND AIMS: Few studies distinguished the independent role of overweight/obesity or their associated-comorbidities in the evolution towards severe forms of COVID-19. Obesity as a unifying risk factor for severe COVID-19 is an emerging hypothesis. The aim of this study was to evaluate whether excessive body weight per se, was a risk factor for developing a severe form of COVID-19. PATIENTS AND METHODS: We included 131 patients hospitalized for COVID-19 pneumonia in a single center of the internal medicine department in Marseille, France. We recorded anthropometric and metabolic parameters such as fasting glycaemia, insulinemia, HOMA-IR, lipids, and all clinical criteria linked to SARS-CoV-2 infection at the admission. Excess body weight was defined by a BMI?>/=?25?kg/m(2). The occurrence of a serious event was defined as a high-debit oxygen requirement over 6?L/min, admission into the intensive care unit, or death. RESULTS: Among 113 patients, two thirds (n?=?76, 67%) had an excess body weight. The number of serious events was significantly higher in excess body weight patients compared to normal weight patients (respectively 25% vs 8%, p?=?0.03) although excess body weight patients were younger (respectively 63.6 vs 70.3?years old, p?=?0.01). In multivariate analyses, the excess body weight status was the only predictor for developing a serious event linked to SARS-CoV-2 infection, with an odds ratio at 5.6 (95% CI: 1.30-23.96; p?=?0.02), independently of previous obesity associated comorbidities. There was a trend towards a positive association between the BMI (normal weight, overweight and obesity) and the risk of serious events linked to COVID-19, with a marked increase from 8.1% to 20% and 30.6% respectively (p?=?0.05). CONCLUSION: Excess body weight was significantly associated with severe forms of the disease, independently of its classical associated comorbidities. Physicians and specialists in Public Health must be sensitized to better protect people with an excess body weight against SARS-CoV-2 infection. Twit Text FOAVip Excess body weight is an independent risk factor for severe forms of COVID-19 ????Metabolism http://www.kidney.de/pget.php?&tw=1&pmid=33421506 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33421506 #FOAvip English Wikipedia <ref>{{Cite pmid|33421506}}</ref> Excess body weight is an independent risk factor for severe forms of COVID-19 #MMPMID33421506 Pietri L; Giorgi R; Begu A; Lojou M; Koubi M; Cauchois R; Grangeot R; Dubois N; Kaplanski G; Valero R; Beliard S Metabolism 2021[Apr]; 117 (ä): 154703 PMID33421506show ga BACKGROUND AND AIMS: Few studies distinguished the independent role of overweight/obesity or their associated-comorbidities in the evolution towards severe forms of COVID-19. Obesity as a unifying risk factor for severe COVID-19 is an emerging hypothesis. The aim of this study was to evaluate whether excessive body weight per se, was a risk factor for developing a severe form of COVID-19. PATIENTS AND METHODS: We included 131 patients hospitalized for COVID-19 pneumonia in a single center of the internal medicine department in Marseille, France. We recorded anthropometric and metabolic parameters such as fasting glycaemia, insulinemia, HOMA-IR, lipids, and all clinical criteria linked to SARS-CoV-2 infection at the admission. Excess body weight was defined by a BMI?>/=?25?kg/m(2). The occurrence of a serious event was defined as a high-debit oxygen requirement over 6?L/min, admission into the intensive care unit, or death. RESULTS: Among 113 patients, two thirds (n?=?76, 67%) had an excess body weight. The number of serious events was significantly higher in excess body weight patients compared to normal weight patients (respectively 25% vs 8%, p?=?0.03) although excess body weight patients were younger (respectively 63.6 vs 70.3?years old, p?=?0.01). In multivariate analyses, the excess body weight status was the only predictor for developing a serious event linked to SARS-CoV-2 infection, with an odds ratio at 5.6 (95% CI: 1.30-23.96; p?=?0.02), independently of previous obesity associated comorbidities. There was a trend towards a positive association between the BMI (normal weight, overweight and obesity) and the risk of serious events linked to COVID-19, with a marked increase from 8.1% to 20% and 30.6% respectively (p?=?0.05). CONCLUSION: Excess body weight was significantly associated with severe forms of the disease, independently of its classical associated comorbidities. Physicians and specialists in Public Health must be sensitized to better protect people with an excess body weight against SARS-CoV-2 infection. |Aged[MESH] |Aged, 80 and over[MESH] |Body Mass Index[MESH] |Body Weight/*physiology[MESH] |COVID-19/*diagnosis/epidemiology/etiology/*pathology[MESH] |Comorbidity[MESH] |Critical Illness[MESH] |Female[MESH] |France/epidemiology[MESH] |Hospitalization/statistics & numerical data[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Obesity/complications/epidemiology[MESH] |Overweight/complications/epidemiology[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2/physiology[MESH]Excess body weight is an independent risk factor for severe forms of C(epmc).pdf DeepDyve Pubget Overpricing