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10.1111/ene.14721 http://scihub22266oqcxt.onion/10.1111/ene.14721 33421278!8014563!33421278     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Neurol 2021 ; 28 (10): 3537-3539 Nephropedia Template TP {{tp|p=33421278|t=2021. Myasthenia gravis associated with anti-MuSK antibodies developed after SARS-CoV-2 infection |pdf=|usr=}}{{33421278}} gab.com Text Myasthenia gravis associated with anti-MuSK antibodies developed after SARS-CoV-2 infection JO: Eur J Neurol http://www.kidney.de/pget.php?&tw=1&pmid=33421278 #FOAvip INTRODUCTION: Since the onset of the novel coronavirus pandemic, several neurological complications secondary to SARS-CoV-2 infection have been reported, affecting central nervous system, peripheral nervous system and neuromuscular junction. CASE REPORT: We present the case of a 77-year-old man who developed bulbar myasthenia gravis (MG) eight weeks after SARS-CoV-2 infection. The search for serum antibodies against the acetylcholine receptor and the muscle-specific tyrosine kinase (MuSK), performed by radioimmunoassay (RIA), and the search of low-density lipoprotein receptor-related protein 4 antibodies, performed by immunohistochemistry, resulted negative, while anti-MuSK antibodies were detected by cell-based assay (CBA). The patient was treated with pyridostigmine (60 mg four times a day) with unsatisfactory clinical response, followed by immunosuppressive therapy (azathioprine 1.5 mg/kg/day) with improvement of MG symptoms after two months of treatment. DISCUSSION: Several viral diseases have been described as associated with the onset of MG, although the underlying mechanisms are not yet fully understood. Similarly, a growing number of scientific reports suggest a correlation between SARS-CoV-2 infection and autoimmune diseases. The interest of our case lies in the timing of the MG onset (after 2 months from infection), together with the unusual late onset of anti-MuSK MG. These elements suggest that coronavirus infection may act as a trigger of the disease. We confirm the importance of CBA in the serological diagnosis of RIA-negative MG. Twit Text FOAVip Myasthenia gravis associated with anti-MuSK antibodies developed after SARS-CoV-2 infection ????Eur J Neurol http://www.kidney.de/pget.php?&tw=1&pmid=33421278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33421278 #FOAvip English Wikipedia <ref>{{Cite pmid|33421278}}</ref> Myasthenia gravis associated with anti-MuSK antibodies developed after SARS-CoV-2 infection #MMPMID33421278 Assini A; Gandoglia I; Damato V; Rikani K; Evoli A; Del Sette M Eur J Neurol 2021[Oct]; 28 (10): 3537-3539 PMID33421278show ga INTRODUCTION: Since the onset of the novel coronavirus pandemic, several neurological complications secondary to SARS-CoV-2 infection have been reported, affecting central nervous system, peripheral nervous system and neuromuscular junction. CASE REPORT: We present the case of a 77-year-old man who developed bulbar myasthenia gravis (MG) eight weeks after SARS-CoV-2 infection. The search for serum antibodies against the acetylcholine receptor and the muscle-specific tyrosine kinase (MuSK), performed by radioimmunoassay (RIA), and the search of low-density lipoprotein receptor-related protein 4 antibodies, performed by immunohistochemistry, resulted negative, while anti-MuSK antibodies were detected by cell-based assay (CBA). The patient was treated with pyridostigmine (60 mg four times a day) with unsatisfactory clinical response, followed by immunosuppressive therapy (azathioprine 1.5 mg/kg/day) with improvement of MG symptoms after two months of treatment. DISCUSSION: Several viral diseases have been described as associated with the onset of MG, although the underlying mechanisms are not yet fully understood. Similarly, a growing number of scientific reports suggest a correlation between SARS-CoV-2 infection and autoimmune diseases. The interest of our case lies in the timing of the MG onset (after 2 months from infection), together with the unusual late onset of anti-MuSK MG. These elements suggest that coronavirus infection may act as a trigger of the disease. We confirm the importance of CBA in the serological diagnosis of RIA-negative MG. |*COVID-19[MESH] |*Myasthenia Gravis/drug therapy[MESH] |Aged[MESH] |Autoantibodies[MESH] |Humans[MESH] |Male[MESH] |Receptors, Cholinergic[MESH] |SARS-CoV-2[MESH]Myasthenia gravis associated with anti-MuSK antibodies developed after(epmc).pdf DeepDyve Pubget Overpricing