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10.1038/s41422-020-00460-y

http://scihub22266oqcxt.onion/10.1038/s41422-020-00460-y
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33420426!7791157!33420426
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suck abstract from ncbi


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pmid33420426      Cell+Res 2021 ; 31 (2): 126-140
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  • AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells #MMPMID33420426
  • Wang S; Qiu Z; Hou Y; Deng X; Xu W; Zheng T; Wu P; Xie S; Bian W; Zhang C; Sun Z; Liu K; Shan C; Lin A; Jiang S; Xie Y; Zhou Q; Lu L; Huang J; Li X
  • Cell Res 2021[Feb]; 31 (2): 126-140 PMID33420426show ga
  • The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to the host receptor ACE2 through its spike (S) glycoprotein, which mediates membrane fusion and viral entry. Although the role of ACE2 as a receptor for SARS-CoV-2 is clear, studies have shown that ACE2 expression is extremely low in various human tissues, especially in the respiratory tract. Thus, other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist. In this study, we found that the tyrosine-protein kinase receptor UFO (AXL) specifically interacts with the N-terminal domain of SARS-CoV-2 S. Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2, we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2, while knocking out AXL significantly reduces SARS-CoV-2 infection in H1299 pulmonary cells and in human primary lung epithelial cells. Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL. The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients. Taken together, our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies.
  • |Axl Receptor Tyrosine Kinase[MESH]
  • |Bronchi/cytology/metabolism[MESH]
  • |COVID-19/*metabolism[MESH]
  • |Cell Line[MESH]
  • |Humans[MESH]
  • |Lung/cytology/metabolism[MESH]
  • |Models, Molecular[MESH]
  • |Protein Interaction Domains and Motifs[MESH]
  • |Proto-Oncogene Proteins/analysis/*metabolism[MESH]
  • |Receptor Protein-Tyrosine Kinases/analysis/*metabolism[MESH]
  • |Respiratory Mucosa/*cytology/metabolism[MESH]
  • |SARS-CoV-2/chemistry/*physiology[MESH]
  • |Spike Glycoprotein, Coronavirus/analysis/*metabolism[MESH]


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