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10.1038/s41598-020-79552-z http://scihub22266oqcxt.onion/10.1038/s41598-020-79552-z 33420163!7794290!33420163     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 3 Nephropedia Template TP {{tp|p=33420163|t=2021. Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples |pdf=|usr=}}{{33420163}} gab.com Text Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33420163 #FOAvip SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung). We report that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I. Twit Text FOAVip Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33420163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33420163 #FOAvip English Wikipedia <ref>{{Cite pmid|33420163}}</ref> Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples #MMPMID33420163 Miller B; Silverstein A; Flores M; Cao K; Kumagai H; Mehta HH; Yen K; Kim SJ; Cohen P Sci Rep 2021[Jan]; 11 (1): 3 PMID33420163show ga SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung). We report that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I. |*SARS-CoV-2[MESH] |*Transcriptome[MESH] |COVID-19/*virology[MESH] |Cell Line[MESH] |DNA, Mitochondrial/*genetics[MESH] |Humans[MESH]Host mitochondrial transcriptome response to SARS-CoV-2 in multiple ce(epmc).pdf DeepDyve Pubget Overpricing