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10.1038/s41467-020-20457-w http://scihub22266oqcxt.onion/10.1038/s41467-020-20457-w 33420022!7794309!33420022     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 134 Nephropedia Template TP {{tp|p=33420022|t=2021. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung |pdf=|usr=}}{{33420022}} gab.com Text Host and viral determinants for efficient SARS-CoV-2 infection of the human lung JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33420022 #FOAvip Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we analyze host and viral determinants essential for efficient SARS-CoV-2 infection in both human lung epithelial cells and ex vivo human lung tissues. We identify heparan sulfate as an important attachment factor for SARS-CoV-2 infection. Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction. While SARS-CoV infection is substantially limited by the sialic acid-mediated restriction in both human lung epithelial cells and ex vivo human lung tissues, infection by SARS-CoV-2 is limited to a lesser extent. We further demonstrate that the furin-like cleavage site in SARS-CoV-2 spike is required for efficient virus replication in human lung but not intestinal tissues. These findings provide insights on the efficient SARS-CoV-2 infection of human lungs. Twit Text FOAVip Host and viral determinants for efficient SARS-CoV-2 infection of the human lung ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33420022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33420022 #FOAvip English Wikipedia <ref>{{Cite pmid|33420022}}</ref> Host and viral determinants for efficient SARS-CoV-2 infection of the human lung #MMPMID33420022 Chu H; Hu B; Huang X; Chai Y; Zhou D; Wang Y; Shuai H; Yang D; Hou Y; Zhang X; Yuen TT; Cai JP; Zhang AJ; Zhou J; Yuan S; To KK; Chan IH; Sit KY; Foo DC; Wong IY; Ng AT; Cheung TT; Law SY; Au WK; Brindley MA; Chen Z; Kok KH; Chan JF; Yuen KY Nat Commun 2021[Jan]; 12 (1): 134 PMID33420022show ga Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and pathogenesis, and reveal targets of intervention. Here, we analyze host and viral determinants essential for efficient SARS-CoV-2 infection in both human lung epithelial cells and ex vivo human lung tissues. We identify heparan sulfate as an important attachment factor for SARS-CoV-2 infection. Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction. While SARS-CoV infection is substantially limited by the sialic acid-mediated restriction in both human lung epithelial cells and ex vivo human lung tissues, infection by SARS-CoV-2 is limited to a lesser extent. We further demonstrate that the furin-like cleavage site in SARS-CoV-2 spike is required for efficient virus replication in human lung but not intestinal tissues. These findings provide insights on the efficient SARS-CoV-2 infection of human lungs. |*Virus Attachment[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Animals[MESH] |COVID-19/*pathology/*transmission[MESH] |Caco-2 Cells[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Cricetinae[MESH] |Furin/metabolism[MESH] |HEK293 Cells[MESH] |Heparitin Sulfate/metabolism[MESH] |Humans[MESH] |Intestinal Mucosa/metabolism[MESH] |Intestines/virology[MESH] |Lung/pathology/virology[MESH] |SARS-CoV-2/physiology[MESH] |Severe Acute Respiratory Syndrome/pathology[MESH] |Sialic Acids/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/*metabolism[MESH] |Vero Cells[MESH] |Virus Internalization[MESH]Host and viral determinants for efficient SARS-CoV-2 infection of the (epmc).pdf DeepDyve Pubget Overpricing