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10.1126/science.abf2946 http://scihub22266oqcxt.onion/10.1126/science.abf2946 33419936!7877493!33419936     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 371 (6530): 708-712 Nephropedia Template TP {{tp|p=33419936|t=2021. Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK |pdf=|usr=}}{{33419936}} gab.com Text Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33419936 #FOAvip The United Kingdom's COVID-19 epidemic during early 2020 was one of world's largest and was unusually well represented by virus genomic sampling. We determined the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes, including 26,181 from the UK sampled throughout the country's first wave of infection. Using large-scale phylogenetic analyses combined with epidemiological and travel data, we quantified the size, spatiotemporal origins, and persistence of genetically distinct UK transmission lineages. Rapid fluctuations in virus importation rates resulted in >1000 lineages; those introduced prior to national lockdown tended to be larger and more dispersed. Lineage importation and regional lineage diversity declined after lockdown, whereas lineage elimination was size-dependent. We discuss the implications of our genetic perspective on transmission dynamics for COVID-19 epidemiology and control. Twit Text FOAVip Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33419936 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33419936 #FOAvip English Wikipedia <ref>{{Cite pmid|33419936}}</ref> Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK #MMPMID33419936 du Plessis L; McCrone JT; Zarebski AE; Hill V; Ruis C; Gutierrez B; Raghwani J; Ashworth J; Colquhoun R; Connor TR; Faria NR; Jackson B; Loman NJ; O'Toole A; Nicholls SM; Parag KV; Scher E; Vasylyeva TI; Volz EM; Watts A; Bogoch II; Khan K; Aanensen DM; Kraemer MUG; Rambaut A; Pybus OG Science 2021[Feb]; 371 (6530): 708-712 PMID33419936show ga The United Kingdom's COVID-19 epidemic during early 2020 was one of world's largest and was unusually well represented by virus genomic sampling. We determined the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes, including 26,181 from the UK sampled throughout the country's first wave of infection. Using large-scale phylogenetic analyses combined with epidemiological and travel data, we quantified the size, spatiotemporal origins, and persistence of genetically distinct UK transmission lineages. Rapid fluctuations in virus importation rates resulted in >1000 lineages; those introduced prior to national lockdown tended to be larger and more dispersed. Lineage importation and regional lineage diversity declined after lockdown, whereas lineage elimination was size-dependent. We discuss the implications of our genetic perspective on transmission dynamics for COVID-19 epidemiology and control. |*Genome, Viral[MESH] |COVID-19/*epidemiology/prevention & control/transmission/*virology[MESH] |Chain of Infection[MESH] |Communicable Disease Control[MESH] |Communicable Diseases, Imported/epidemiology/virology[MESH] |Epidemics[MESH] |Humans[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics[MESH] |Travel[MESH]Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the U(epmc).pdf DeepDyve Pubget Overpricing