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10.3390/cells10010082

http://scihub22266oqcxt.onion/10.3390/cells10010082
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33419040!7825305!33419040
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suck abstract from ncbi


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pmid33419040      Cells 2021 ; 10 (1): ä
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  • Usefulness of the New Hematological Parameter: Reactive Lymphocytes RE-LYMP with Flow Cytometry Markers of Inflammation in COVID-19 #MMPMID33419040
  • Rutkowska E; Kwiecien I; Kulik K; Chelstowska B; Klos K; Rzepecki P; Chcialowski A
  • Cells 2021[Jan]; 10 (1): ä PMID33419040show ga
  • Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it with activation lymphocytes markers by flow cytometry. The study group consisted of 40 patients: with COVID-19 infection (n = 20) and with others virus infections without COVID-19 (COVID-19(-) virus (n = 20)) and 20 healthy donors (HC). Blood count and flow cytometry were performed. The COVID-19(+) group had significantly lower RE-LYMP parameter than the COVID-19(-) virus group (5.45 vs. 11.05, p < 0.05). We observed higher proportion of plasmablasts in the COVID-19(+) and COVID-19(-) virus groups than HC (8.8 vs. 11.1 vs. 2.7, p < 0.05). In the COVID-19(+) there was a lower proportion of CD4+ CD38+ cells than in the other groups (significant differences between COVID-19(+) and COVID-19(-) virus groups). RE-LYMP correlated with activated T lymphocytes CD38+ and HLA-DR+ in the COVID-19(-) virus group, however in the COVID-19(+) group correlations with T lymphocytes CD25+ and CD45RO+ were observed. In summary the analysis of the RE-LYMP together with flow cytometric activation markers can be helpful in identifying and distinguishing patients with COVID-19(+) from other viruses and HC.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/epidemiology/*immunology[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Flow Cytometry[MESH]
  • |Humans[MESH]
  • |Immunophenotyping[MESH]
  • |Inflammation/*immunology[MESH]
  • |Lymphocyte Subsets/*immunology[MESH]
  • |Male[MESH]


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