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10.3390/biom11010065 http://scihub22266oqcxt.onion/10.3390/biom11010065 33419007!7825278!33419007     free     free     free       Biomolecules 2021 ; 11 (1): ? Nephropedia Template TP {{tp|p=33419007|t=2021. Endolysosomal TRPMLs in Cancer |pdf=|usr=}}{{33419007}} gab.com Text Endolysosomal TRPMLs in Cancer JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=33419007 #FOAvip Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca(2+) stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca(2+) is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca(2+)-permeable channels Transient Receptor Potential (TRP) Mucolipins (TRPMLs, TRPML1-3) integrate multiple processes of cell growth, division and metabolism. Dysregulation of TRPMLs activity has been implicated in cancer development. In this review, we provide a summary of the latest development of TRPMLs in cancer. The expression of TRPMLs in cancer, TRPMLs in cancer cell nutrient sensing, TRPMLs-mediated lysosomal exocytosis in cancer development, TRPMLs in TFEB-mediated gene transcription of cancer cells, TRPMLs in bacteria-related cancer development and TRPMLs-regulated antitumor immunity are discussed. We hope to guide readers toward a more in-depth discussion of the importance of lysosomal TRPMLs in cancer progression and other human diseases. Twit Text FOAVip Endolysosomal TRPMLs in Cancer ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=33419007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33419007 #FOAvip English Wikipedia <ref>{{Cite pmid|33419007}}</ref> Endolysosomal TRPMLs in Cancer #MMPMID33419007 Xu M; Dong XP Biomolecules 2021[Jan]; 11 (1): ? PMID33419007show ga Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca(2+) stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca(2+) is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca(2+)-permeable channels Transient Receptor Potential (TRP) Mucolipins (TRPMLs, TRPML1-3) integrate multiple processes of cell growth, division and metabolism. Dysregulation of TRPMLs activity has been implicated in cancer development. In this review, we provide a summary of the latest development of TRPMLs in cancer. The expression of TRPMLs in cancer, TRPMLs in cancer cell nutrient sensing, TRPMLs-mediated lysosomal exocytosis in cancer development, TRPMLs in TFEB-mediated gene transcription of cancer cells, TRPMLs in bacteria-related cancer development and TRPMLs-regulated antitumor immunity are discussed. We hope to guide readers toward a more in-depth discussion of the importance of lysosomal TRPMLs in cancer progression and other human diseases. |Animals[MESH] |Autophagy/genetics[MESH] |Endosomes/*metabolism[MESH] |Humans[MESH] |Immunity/genetics[MESH] |Lysosomes/*metabolism[MESH] |Neoplasms/genetics/immunology/*metabolism[MESH]Endolysosomal TRPMLs in Cancer (epmc).pdf DeepDyve Pubget Overpricing