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10.1016/j.imbio.2020.152052 http://scihub22266oqcxt.onion/10.1016/j.imbio.2020.152052 33418320!7833102!33418320     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33418320&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunobiology 2021 ; 226 (1): 152052 Nephropedia Template TP {{tp|p=33418320|t=2021. BCG immunomodulation: From the hygiene hypothesis to COVID-19 |pdf=|usr=}}{{33418320}} gab.com Text BCG immunomodulation: From the hygiene hypothesis to COVID-19 JO: Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=33418320 #FOAvip The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG vaccine is safe, cheap, widely available, amendable to use as a recombinant vector, and immunogenic, it has immense potential for use as an immunotherapeutic agent for various conditions including autoimmune, allergic, neurodegenerative, and neoplastic diseases as well as a preventive measure against infectious agents. Of particular interest is the use of BCG vaccination to counteract the increasing prevalence of autoimmune and allergic conditions in industrialized countries attributable to reduced infectious burden as described by the 'hygiene hypothesis.' Furthermore, BCG vaccination has been proposed as a potential therapy to mitigate spread and disease burden of COVID-19 as a bridge to development of a specific vaccine and recombinant BCG expression vectors may prove useful for the introduction of SARS-CoV-2 antigens (rBCG-SARS-CoV-2) to induce long-term immunity. Understanding the immunomodulatory effects of BCG vaccine in these disease contexts is therefore critical. To that end, we review here BCG-induced immunomodulation focusing specifically on BCG-induced trained immunity and how it relates to the 'hygiene hypothesis' and COVID-19. Twit Text FOAVip BCG immunomodulation: From the hygiene hypothesis to COVID-19 ????Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=33418320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33418320 #FOAvip English Wikipedia <ref>{{Cite pmid|33418320}}</ref> BCG immunomodulation: From the hygiene hypothesis to COVID-19 #MMPMID33418320 Moulson AJ; Av-Gay Y Immunobiology 2021[Jan]; 226 (1): 152052 PMID33418320show ga The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG vaccine is safe, cheap, widely available, amendable to use as a recombinant vector, and immunogenic, it has immense potential for use as an immunotherapeutic agent for various conditions including autoimmune, allergic, neurodegenerative, and neoplastic diseases as well as a preventive measure against infectious agents. Of particular interest is the use of BCG vaccination to counteract the increasing prevalence of autoimmune and allergic conditions in industrialized countries attributable to reduced infectious burden as described by the 'hygiene hypothesis.' Furthermore, BCG vaccination has been proposed as a potential therapy to mitigate spread and disease burden of COVID-19 as a bridge to development of a specific vaccine and recombinant BCG expression vectors may prove useful for the introduction of SARS-CoV-2 antigens (rBCG-SARS-CoV-2) to induce long-term immunity. Understanding the immunomodulatory effects of BCG vaccine in these disease contexts is therefore critical. To that end, we review here BCG-induced immunomodulation focusing specifically on BCG-induced trained immunity and how it relates to the 'hygiene hypothesis' and COVID-19. |*Hygiene Hypothesis[MESH] |*Immunity, Innate[MESH] |BCG Vaccine/*immunology/*therapeutic use[MESH] |COVID-19/*immunology/*therapy/virology[MESH] |Humans[MESH]BCG immunomodulation: From the hygiene hypothesis to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing