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10.1016/j.rvsc.2020.12.023 http://scihub22266oqcxt.onion/10.1016/j.rvsc.2020.12.023 33418186!ä!33418186 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Res+Vet+Sci 2021 ; 135 (ä): 15-19 Nephropedia Template TP {{tp|p=33418186|t=2021. Mutation analysis of the spike protein in Italian feline infectious peritonitis virus and feline enteric coronavirus sequences |pdf=|usr=}}{{33418186}} gab.com Text Mutation analysis of the spike protein in Italian feline infectious peritonitis virus and feline enteric coronavirus sequences JO: Res Vet Sci http://www.kidney.de/pget.php?&tw=1&pmid=33418186 #FOAvip Feline coronavirus (FCoV) exists as two different genotypes, FCoV type I and II, each including two biotypes, feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV), the latter being a virulent variant originating from the former virus. Recently, two amino acid substitutions, M1058L and S1060A, within the spike protein have been associated to the FECV/FIPV virulence change. In this study, we have analysed the frequency of detection of such mutations in FIPV and FECV strains circulating in Italian cats and obtained information about their evolutionary relationships with reference isolates. A total of 40 FCoV strains, including 19 strains from effusions or tissue samples of FIP cats and 21 strains from faecal samples of non-FIP cats, were analysed. Mutation M1058L was detected in 16/18 FCoV-I and 1/1 FCoV-II strains associated with FIP, while change S1060A was presented by two FIPV strains. By phylogenetic analysis, FCoV sequences clustered according to the genotype but not according to the biotype, with FECV/FIPV strains recovered from the same animal being closely related. Further studies are needed to better define the genetic signatures associated with the FECV/FIPV virulence shift. Twit Text FOAVip Mutation analysis of the spike protein in Italian feline infectious peritonitis virus and feline enteric coronavirus sequences ????Res Vet Sci http://www.kidney.de/pget.php?&tw=1&pmid=33418186 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33418186 #FOAvip English Wikipedia <ref>{{Cite pmid|33418186}}</ref> Mutation analysis of the spike protein in Italian feline infectious peritonitis virus and feline enteric coronavirus sequences #MMPMID33418186 Decaro N; Mari V; Lanave G; Lorusso E; Lucente MS; Desario C; Colaianni ML; Elia G; Ferringo F; Alfano F; Buonavoglia C Res Vet Sci 2021[Mar]; 135 (ä): 15-19 PMID33418186show ga Feline coronavirus (FCoV) exists as two different genotypes, FCoV type I and II, each including two biotypes, feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV), the latter being a virulent variant originating from the former virus. Recently, two amino acid substitutions, M1058L and S1060A, within the spike protein have been associated to the FECV/FIPV virulence change. In this study, we have analysed the frequency of detection of such mutations in FIPV and FECV strains circulating in Italian cats and obtained information about their evolutionary relationships with reference isolates. A total of 40 FCoV strains, including 19 strains from effusions or tissue samples of FIP cats and 21 strains from faecal samples of non-FIP cats, were analysed. Mutation M1058L was detected in 16/18 FCoV-I and 1/1 FCoV-II strains associated with FIP, while change S1060A was presented by two FIPV strains. By phylogenetic analysis, FCoV sequences clustered according to the genotype but not according to the biotype, with FECV/FIPV strains recovered from the same animal being closely related. Further studies are needed to better define the genetic signatures associated with the FECV/FIPV virulence shift. |Amino Acid Substitution[MESH] |Animals[MESH] |Cat Diseases/*virology[MESH] |Cats[MESH] |Cluster Analysis[MESH] |Coronavirus Infections/*veterinary/virology[MESH] |Coronavirus, Feline/*genetics/isolation & purification/pathogenicity[MESH] |Feces/virology[MESH] |Feline Infectious Peritonitis/*virology[MESH] |Genotype[MESH] |Italy[MESH] |Mutation[MESH] |Phylogeny[MESH]Mutation analysis of the spike protein in Italian feline infectious pe(epmc).pdf DeepDyve Pubget Overpricing