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10.1016/j.virusres.2020.198283

http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198283
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suck abstract from ncbi


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pmid33418027      Virus+Res 2021 ; 295 (ä): 198283
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  • Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) #MMPMID33418027
  • Scagnolari C; Pierangeli A; Frasca F; Bitossi C; Viscido A; Oliveto G; Scordio M; Mazzuti L; Di Carlo D; Gentile M; Solimini A; Ceccarelli G; Pugliese F; Mastroianni CM; d'Ettorre G; Turriziani O; Antonelli G
  • Virus Res 2021[Apr]; 295 (ä): 198283 PMID33418027show ga
  • The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interferon Lambda[MESH]
  • |Interferon Type I/*genetics[MESH]
  • |Interferons/*genetics[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oropharynx/*immunology[MESH]


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