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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Virus+Res 2021 ; 295 (ä): 198283 Nephropedia Template TP
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Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) #MMPMID33418027
Scagnolari C; Pierangeli A; Frasca F; Bitossi C; Viscido A; Oliveto G; Scordio M; Mazzuti L; Di Carlo D; Gentile M; Solimini A; Ceccarelli G; Pugliese F; Mastroianni CM; d'Ettorre G; Turriziani O; Antonelli G
Virus Res 2021[Apr]; 295 (ä): 198283 PMID33418027show ga
The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.