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10.1542/peds.2020-027763

http://scihub22266oqcxt.onion/10.1542/peds.2020-027763
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33414238!8015148!33414238
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suck abstract from ncbi


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pmid33414238      Pediatrics 2021 ; 147 (4): ä
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  • Inflammatory Bowel Disease Presenting With Concurrent COVID-19 Multisystem Inflammatory Syndrome #MMPMID33414238
  • Sweeny KF; Zhang YJ; Crume B; Martz CA; Blessing MM; Kahn SA
  • Pediatrics 2021[Apr]; 147 (4): ä PMID33414238show ga
  • Coronavirus disease 2019 is associated with a postinfectious multisystem inflammatory syndrome in children (MIS-C). This syndrome is marked by cytokine storm and multiorgan dysfunction, often affecting the gastrointestinal tract, the heart, and the hematopoietic system. We describe the case of a 16-year-old boy with an initial presentation of severe inflammatory bowel disease and concurrent MIS-C. He presented with abdominal pain, diarrhea, and hematochezia and met criteria for the systemic inflammatory response syndrome. Laboratory inflammatory profiling revealed markedly elevated ferritin, D-dimer, C-reactive protein, soluble interleukin 2, and interleukin 6 levels. Endoscopy and colonoscopy revealed severe active gastroduodenitis, patchy colitis, and a normal-appearing terminal ileum. The patient was treated with a combination of steroids, intravenous immunoglobulin, and infliximab, and his symptoms slowly resolved over a 3-week period. In this case, we describe coincident MIS-C with a remarkably severe and difficult-to-treat initial presentation of inflammatory bowel disease and highlight the need to investigate the effect of coronavirus disease 2019 and MIS-C on inflammatory disorders.
  • |Adolescent[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*complications/diagnosis[MESH]
  • |Humans[MESH]
  • |Inflammatory Bowel Diseases/*complications/diagnosis/drug therapy[MESH]
  • |Male[MESH]


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