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10.1016/j.mayocp.2020.10.032

http://scihub22266oqcxt.onion/10.1016/j.mayocp.2020.10.032
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33413813!7604071!33413813
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suck abstract from ncbi


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pmid33413813      Mayo+Clin+Proc 2021 ; 96 (1): 156-164
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  • Association of Timing and Balance of Physical Activity and Rest/Sleep With Risk of COVID-19: A UK Biobank Study #MMPMID33413813
  • Rowlands AV; Kloecker DE; Chudasama Y; Davies MJ; Dawkins NP; Edwardson CL; Gillies C; Khunti K; Razieh C; Islam N; Zaccardi F; Yates T
  • Mayo Clin Proc 2021[Jan]; 96 (1): 156-164 PMID33413813show ga
  • Behavioral lifestyle factors are associated with cardiometabolic disease and obesity, which are risk factors for coronavirus disease 2019 (COVID-19). We aimed to investigate whether physical activity, and the timing and balance of physical activity and sleep/rest, were associated with SARS-CoV-2 positivity and COVID-19 severity. Data from 91,248 UK Biobank participants with accelerometer data and complete covariate and linked COVID-19 data to July 19, 2020, were included. The risk of SARS-CoV-2 positivity and COVID-19 severity-in relation to overall physical activity, moderate-to-vigorous physical activity (MVPA), balance between activity and sleep/rest, and variability in timing of sleep/rest-was assessed with adjusted logistic regression. Of 207 individuals with a positive test result, 124 were classified as having a severe infection. Overall physical activity and MVPA were not associated with severe COVID-19, whereas a poor balance between activity and sleep/rest was (odds ratio [OR] per standard deviation: 0.71; 95% confidence interval [CI], 0.62 to 0.81]). This finding was related to higher daytime activity being associated with lower risk (OR, 0.75; 95% CI, 0.61 to 0.93) but higher movement during sleep/rest being associated with higher risk (OR, 1.26; 95% CI, 1.12 to 1.42) of severe infection. Greater variability in timing of sleep/rest was also associated with increased risk (OR, 1.21; 95% CI, 1.08 to 1.35). Results for testing positive were broadly consistent. In conclusion, these results highlight the importance of not just physical activity, but also quality sleep/rest and regular sleep/rest patterns, on risk of COVID-19. Our findings indicate the risk of COVID-19 was consistently approximately 1.2-fold greater per approximately 40-minute increase in variability in timing of proxy measures of sleep, indicative of irregular sleeping patterns.
  • |*Exercise[MESH]
  • |*Rest[MESH]
  • |*Sleep[MESH]
  • |Accelerometry[MESH]
  • |Aged[MESH]
  • |Biological Specimen Banks[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Prospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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