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10.1186/s13073-020-00822-6

http://scihub22266oqcxt.onion/10.1186/s13073-020-00822-6
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suck abstract from ncbi


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pmid33413610      Genome+Med 2021 ; 13 (1): 4
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  • An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets #MMPMID33413610
  • Ward D; Higgins M; Phelan JE; Hibberd ML; Campino S; Clark TG
  • Genome Med 2021[Jan]; 13 (1): 4 PMID33413610show ga
  • During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online "immuno-analytics" resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from: http://genomics.lshtm.ac.uk/immuno (online); https://github.com/dan-ward-bio/COVID-immunoanalytics (source code).
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines[MESH]
  • |COVID-19/diagnosis/prevention & control[MESH]
  • |Computer Simulation[MESH]
  • |Coronavirus Nucleocapsid Proteins/genetics/immunology[MESH]
  • |Epitopes, B-Lymphocyte/immunology[MESH]
  • |Histocompatibility Antigens Class I/immunology[MESH]
  • |Humans[MESH]
  • |Mutation[MESH]
  • |Phosphoproteins/genetics/immunology[MESH]
  • |SARS-CoV-2/*genetics/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH]


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