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10.19191/EP20.5-6.S2.118 http://scihub22266oqcxt.onion/10.19191/EP20.5-6.S2.118 33412810!ä!33412810 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epidemiol+Prev 2020 ; 44 (5-6 Suppl 2): 193-199 Nephropedia Template TP {{tp|p=33412810|t=2020. Valutazione di una strategia di screening per l'infezione da SARS-CoV-2 basata su test sierologici |pdf=|usr=}}{{33412810}} gab.com Text Valutazione di una strategia di screening per l'infezione da SARS-CoV-2 basata su test sierologici JO: Epidemiol Prev http://www.kidney.de/pget.php?&tw=1&pmid=33412810 #FOAvip BACKGROUND: facing the SARS-CoV-2 epidemic requires intensive testing on the population to early identify and isolate infected subjects. Although RT-PCR is the most reliable technique to detect ongoing infections, serological tests are frequently proposed as tools in heterogeneous screening strategies. OBJECTIVES: to analyse the performance of a screening strategy proposed by the local government of Tuscany (Central Italy), which first uses qualitative rapid tests for antibody detection, and then RT-PCR tests on the positive subjects. METHODS: a simulation study is conducted to investigate the number of RT-PCR tests required by the screening strategy and the undetected ongoing infections in a pseudo-population of 500,000 subjects, under different prevalence scenarios and assuming a sensitivity of the serological test ranging from 0.50 to 0.80 (specificity 0.98). A compartmental model is used to predict the number of new infections generated by the false negatives two months after the screening, under different values of the infection reproduction number. RESULTS: assuming a sensitivity equal to 0.80 and a prevalence of 0.3%, the screening procedure would require on average 11,167 RT-PCR tests and would produce 300 false negatives, responsible after two months of a number of contagions ranging from 526 to 1,132, under the optimistic scenario of a reproduction number between 0.5 to 1. Resources and false negatives increase with the prevalence. CONCLUSIONS: the analysed screening procedure should be avoided unless the prevalence and the rate of contagion are very low. The cost and effectiveness of the screening strategies should be evaluated in the actual context of the epidemic, accounting for the fact that it may change over time. Twit Text FOAVip Valutazione di una strategia di screening per l'infezione da SARS-CoV-2 basata su test sierologici ????Epidemiol Prev http://www.kidney.de/pget.php?&tw=1&pmid=33412810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33412810 #FOAvip English Wikipedia <ref>{{Cite pmid|33412810}}</ref> Valutazione di una strategia di screening per l'infezione da SARS-CoV-2 basata su test sierologici #MMPMID33412810 Baccini M; Mattei A; Rocco E; Vannucci G; Mealli F Epidemiol Prev 2020[Sep]; 44 (5-6 Suppl 2): 193-199 PMID33412810show ga BACKGROUND: facing the SARS-CoV-2 epidemic requires intensive testing on the population to early identify and isolate infected subjects. Although RT-PCR is the most reliable technique to detect ongoing infections, serological tests are frequently proposed as tools in heterogeneous screening strategies. OBJECTIVES: to analyse the performance of a screening strategy proposed by the local government of Tuscany (Central Italy), which first uses qualitative rapid tests for antibody detection, and then RT-PCR tests on the positive subjects. METHODS: a simulation study is conducted to investigate the number of RT-PCR tests required by the screening strategy and the undetected ongoing infections in a pseudo-population of 500,000 subjects, under different prevalence scenarios and assuming a sensitivity of the serological test ranging from 0.50 to 0.80 (specificity 0.98). A compartmental model is used to predict the number of new infections generated by the false negatives two months after the screening, under different values of the infection reproduction number. RESULTS: assuming a sensitivity equal to 0.80 and a prevalence of 0.3%, the screening procedure would require on average 11,167 RT-PCR tests and would produce 300 false negatives, responsible after two months of a number of contagions ranging from 526 to 1,132, under the optimistic scenario of a reproduction number between 0.5 to 1. Resources and false negatives increase with the prevalence. CONCLUSIONS: the analysed screening procedure should be avoided unless the prevalence and the rate of contagion are very low. The cost and effectiveness of the screening strategies should be evaluated in the actual context of the epidemic, accounting for the fact that it may change over time. |*COVID-19 Serological Testing/economics/methods[MESH] |*Computer Simulation[MESH] |*Models, Theoretical[MESH] |*Pandemics[MESH] |Antibodies, Viral/*blood[MESH] |Basic Reproduction Number[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/*diagnosis/epidemiology/transmission[MESH] |Cost-Benefit Analysis[MESH] |False Negative Reactions[MESH] |False Positive Reactions[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Mass Screening/economics/*methods[MESH] |Monte Carlo Method[MESH] |Point-of-Care Testing/economics[MESH] |Prevalence[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |SARS-CoV-2/*immunology[MESH]Valutazione di una strategia di screening per l'infezione da SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing