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10.1016/j.mehy.2020.110470 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110470 33412501!7837050!33412501     free     free     free       Med+Hypotheses 2021 ; 146 (ä): 110470 Nephropedia Template TP {{tp|p=33412501|t=2021. Polycations and polyanions in SARS-CoV-2 infection |pdf=|usr=}}{{33412501}} gab.com Text Polycations and polyanions in SARS-CoV-2 infection JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33412501 #FOAvip We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids. Twit Text FOAVip Polycations and polyanions in SARS-CoV-2 infection ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=33412501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33412501 #FOAvip English Wikipedia <ref>{{Cite pmid|33412501}}</ref> Polycations and polyanions in SARS-CoV-2 infection #MMPMID33412501 Ginsburg I; Fibach E Med Hypotheses 2021[Jan]; 146 (ä): 110470 PMID33412501show ga We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids. |*Models, Biological[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*etiology/*metabolism[MESH] |Endocytosis[MESH] |Heparin/therapeutic use[MESH] |Histones/metabolism[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Neutrophils/metabolism[MESH] |Pandemics[MESH] |Polyelectrolytes/*metabolism/therapeutic use[MESH] |SARS-CoV-2/drug effects/pathogenicity/physiology[MESH] |Static Electricity[MESH]Polycations and polyanions in SARS-CoV-2 infection (epmc).pdf DeepDyve Pubget Overpricing