Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1371/journal.ppat.1009033

http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009033
suck pdf from google scholar
33411764!7790267!33411764
unlimited free pdf from europmc33411764    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid33411764      PLoS+Pathog 2021 ; 17 (1): e1009033
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Novel modulators of p53-signaling encoded by unknown genes of emerging viruses #MMPMID33411764
  • Alzhanova D; Corcoran K; Bailey AG; Long K; Taft-Benz S; Graham RL; Broussard GS; Heise M; Neumann G; Halfmann P; Kawaoka Y; Baric RS; Damania B; Dittmer DP
  • PLoS Pathog 2021[Jan]; 17 (1): e1009033 PMID33411764show ga
  • The p53 transcription factor plays a key role both in cancer and in the cell-intrinsic response to infections. The ORFEOME project hypothesized that novel p53-virus interactions reside in hitherto uncharacterized, unknown, or hypothetical open reading frames (orfs) of human viruses. Hence, 172 orfs of unknown function from the emerging viruses SARS-Coronavirus, MERS-Coronavirus, influenza, Ebola, Zika (ZIKV), Chikungunya and Kaposi Sarcoma-associated herpesvirus (KSHV) were de novo synthesized, validated and tested in a functional screen of p53 signaling. This screen revealed novel mechanisms of p53 virus interactions and two viral proteins KSHV orf10 and ZIKV NS2A binding to p53. Originally identified as the target of small DNA tumor viruses, these experiments reinforce the notion that all viruses, including RNA viruses, interfere with p53 functions. These results validate this resource for analogous systems biology approaches to identify functional properties of uncharacterized viral proteins, long non-coding RNAs and micro RNAs.
  • |Chikungunya virus/genetics/metabolism[MESH]
  • |Communicable Diseases, Emerging/*virology[MESH]
  • |Coronavirus/genetics/metabolism[MESH]
  • |Ebolavirus/genetics/metabolism[MESH]
  • |Herpesvirus 8, Human/genetics/metabolism[MESH]
  • |Humans[MESH]
  • |Influenza A virus/genetics/metabolism[MESH]
  • |Open Reading Frames[MESH]
  • |RNA Viruses/genetics/*metabolism[MESH]
  • |Signal Transduction/*genetics[MESH]
  • |Tumor Suppressor Protein p53/genetics/*metabolism[MESH]
  • |Viral Nonstructural Proteins/metabolism[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box