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10.1111/joim.13208 http://scihub22266oqcxt.onion/10.1111/joim.13208 33411411!ä!33411411 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Intern+Med 2021 ; 289 (6): 861-872 Nephropedia Template TP {{tp|p=33411411|t=2021. Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage |pdf=|usr=}}{{33411411}} gab.com Text Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage JO: J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=33411411 #FOAvip BACKGROUND: Since the first observations of patients with COVID-19, significant hypoalbuminaemia was detected. Its causes have not been investigated yet. OBJECTIVE: We hypothesized that pulmonary capillary leakage affects the severity of respiratory failure, causing a shift of fluids and proteins through the epithelial-endothelial barrier. METHODS: One hundred seventy-four COVID-19 patients with respiratory symptoms, 92 admitted to the intermediate medicine ward (IMW) and 82 to the intensive care unit (ICU) at Luigi Sacco Hospital in Milan, were studied. RESULTS: Baseline characteristics at admission were considered. Proteins, interleukin 8 (IL-8) and interleukin 10 (IL-10) in bronchoalveolar lavage fluid (BALF) were analysed in 26 ICU patients. In addition, ten autopsy ultrastructural lung studies were performed in patients with COVID-19 and compared with postmortem findings in a control group (bacterial pneumonia-ARDS and H1N1-ARDS). ICU patients had lower serum albumin than IMW patients [20 (18-23) vs 28 (24-33) g L(-1) , P < 0.001]. Serum albumin was lower in more compromised groups (lower PaO(2) -to-FiO(2) ratio and worst chest X-ray findings) and was associated with 30 days of probability of survival. Protein concentration was correlated with IL-8 and IL-10 levels in BALF. Electron microscopy examinations of eight out of ten COVID-19 lung tissues showed loosening of junctional complexes, quantitatively more pronounced than in controls, and direct viral infection of type 2 pneumocytes and endothelial cells. CONCLUSION: Hypoalbuminaemia may serve as severity marker of epithelial-endothelial damage in patients with COVID-19. There are clues that pulmonary capillary leak syndrome plays a key role in the pathogenesis of COVID-19 and might be a potential therapeutic target. Twit Text FOAVip Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage ????J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=33411411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33411411 #FOAvip English Wikipedia <ref>{{Cite pmid|33411411}}</ref> Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage #MMPMID33411411 Wu MA; Fossali T; Pandolfi L; Carsana L; Ottolina D; Frangipane V; Rech R; Tosoni A; Lopez G; Agarossi A; Cogliati C; Meloni F; Marchini B; Nebuloni M; Catena E; Colombo R J Intern Med 2021[Jun]; 289 (6): 861-872 PMID33411411show ga BACKGROUND: Since the first observations of patients with COVID-19, significant hypoalbuminaemia was detected. Its causes have not been investigated yet. OBJECTIVE: We hypothesized that pulmonary capillary leakage affects the severity of respiratory failure, causing a shift of fluids and proteins through the epithelial-endothelial barrier. METHODS: One hundred seventy-four COVID-19 patients with respiratory symptoms, 92 admitted to the intermediate medicine ward (IMW) and 82 to the intensive care unit (ICU) at Luigi Sacco Hospital in Milan, were studied. RESULTS: Baseline characteristics at admission were considered. Proteins, interleukin 8 (IL-8) and interleukin 10 (IL-10) in bronchoalveolar lavage fluid (BALF) were analysed in 26 ICU patients. In addition, ten autopsy ultrastructural lung studies were performed in patients with COVID-19 and compared with postmortem findings in a control group (bacterial pneumonia-ARDS and H1N1-ARDS). ICU patients had lower serum albumin than IMW patients [20 (18-23) vs 28 (24-33) g L(-1) , P < 0.001]. Serum albumin was lower in more compromised groups (lower PaO(2) -to-FiO(2) ratio and worst chest X-ray findings) and was associated with 30 days of probability of survival. Protein concentration was correlated with IL-8 and IL-10 levels in BALF. Electron microscopy examinations of eight out of ten COVID-19 lung tissues showed loosening of junctional complexes, quantitatively more pronounced than in controls, and direct viral infection of type 2 pneumocytes and endothelial cells. CONCLUSION: Hypoalbuminaemia may serve as severity marker of epithelial-endothelial damage in patients with COVID-19. There are clues that pulmonary capillary leak syndrome plays a key role in the pathogenesis of COVID-19 and might be a potential therapeutic target. |Aged[MESH] |Bronchoalveolar Lavage Fluid/chemistry[MESH] |COVID-19/blood/*complications[MESH] |Capillary Leak Syndrome/etiology[MESH] |Endothelium, Vascular/pathology[MESH] |Female[MESH] |Humans[MESH] |Hypoalbuminemia/*etiology[MESH] |Interleukin-10/analysis[MESH] |Interleukin-8/analysis[MESH] |Lung/diagnostic imaging/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Respiratory Mucosa/pathology[MESH] |Retrospective Studies[MESH]Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying p(epmc).pdf DeepDyve Pubget Overpricing