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10.3389/fimmu.2020.600405 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.600405 33408715!7779612!33408715     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 600405 Nephropedia Template TP {{tp|p=33408715|t=2020. Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19 |pdf=|usr=}}{{33408715}} gab.com Text Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33408715 #FOAvip Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response. Whether preservation of T cells, prevention of their aberrant differentiation, and expansion of their population may alter disease course is unknown. Its investigation requires experimental interrogation of the linked differentiation and death pathway by agents known to uncouple T cell proliferation and differentiation in both CD4+ and CD8+ T cells. Twit Text FOAVip Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33408715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33408715 #FOAvip English Wikipedia <ref>{{Cite pmid|33408715}}</ref> Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19 #MMPMID33408715 Leonardi AJ; Proenca RB Front Immunol 2020[]; 11 (ä): 600405 PMID33408715show ga Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response. Whether preservation of T cells, prevention of their aberrant differentiation, and expansion of their population may alter disease course is unknown. Its investigation requires experimental interrogation of the linked differentiation and death pathway by agents known to uncouple T cell proliferation and differentiation in both CD4+ and CD8+ T cells. |Apoptosis/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology/pathology[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |COVID-19/*immunology/pathology[MESH] |Cell Differentiation/*immunology[MESH] |Humans[MESH] |Proto-Oncogene Proteins c-akt/*immunology[MESH] |SARS-CoV-2/*immunology[MESH]Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covi(epmc).pdf DeepDyve Pubget Overpricing