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10.1126/science.abf4063

http://scihub22266oqcxt.onion/10.1126/science.abf4063
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33408181!7919858!33408181
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suck abstract from ncbi


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pmid33408181      Science 2021 ; 371 (6529): ä
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  • Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection #MMPMID33408181
  • Dan JM; Mateus J; Kato Y; Hastie KM; Yu ED; Faliti CE; Grifoni A; Ramirez SI; Haupt S; Frazier A; Nakao C; Rayaprolu V; Rawlings SA; Peters B; Krammer F; Simon V; Saphire EO; Smith DM; Weiskopf D; Sette A; Crotty S
  • Science 2021[Feb]; 371 (6529): ä PMID33408181show ga
  • Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at >/=6 months after infection. Immunoglobulin G (IgG) to the spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month after symptom onset. SARS-CoV-2-specific CD4(+) T cells and CD8(+) T cells declined with a half-life of 3 to 5 months. By studying antibody, memory B cell, CD4(+) T cell, and CD8(+) T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.
  • |*Immunologic Memory[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Neutralizing/blood[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |B-Lymphocytes/immunology[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |United States[MESH]


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