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10.1192/bjp.2020.251

http://scihub22266oqcxt.onion/10.1192/bjp.2020.251
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33407954!ä!33407954

suck abstract from ncbi


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pmid33407954      Br+J+Psychiatry 2021 ; 218 (6): 344-351
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  • Association of mental disorders with SARS-CoV-2 infection and severe health outcomes: nationwide cohort study #MMPMID33407954
  • Jeon HL; Kwon JS; Park SH; Shin JY
  • Br J Psychiatry 2021[Jun]; 218 (6): 344-351 PMID33407954show ga
  • BACKGROUND: Epidemiological data on the association between mental disorders and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) severity are limited. AIMS: To evaluate the association between mental disorders and the risk of SARS-CoV-2 infection and severe outcomes following COVID-19. METHOD: We performed a cohort study using the Korean COVID-19 patient database based on national health insurance data. Each person with a mental or behavioural disorder (diagnosed during the 6 months prior to their first SARS-CoV-2 test) was matched by age, gender and Charlson Comorbidity Index with up to four people without mental disorders. SARS-CoV-2-positivity risk and the risk of death or severe events (intensive care unit admission, use of mechanical ventilation and acute respiratory distress syndrome) post-infection were calculated using conditional logistic regression analysis. RESULTS: Among 230 565 people tested for SARS-CoV-2, 33 653 (14.6%) had mental disorders; 928/33 653 (2.76%) tested SARS-CoV-2 positive and 56/928 (6.03%) died. In multivariable analysis using the matched cohort, there was no association between mental disorders and SARS-CoV-2-positivity risk (odds ratio OR = 0.95; 95% CI 0.87-1.04); however, a higher risk was associated with schizophrenia-related disorders (OR = 1.50; 95% CI 1.14-1.99). Among confirmed COVID-19 patients, the mortality risk was significantly higher in patients with than in those without mental disorders (OR = 1.99, 95% CI 1.15-3.43). CONCLUSIONS: Mental disorders are likely contributing factors to mortality following COVID-19. Although the infection risk was not higher for people with mental disorders overall, those with schizophrenia-related disorders were more vulnerable to infection.
  • |*COVID-19[MESH]
  • |*Mental Disorders/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Disease Susceptibility[MESH]
  • |Humans[MESH]


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