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10.1186/s12890-020-01388-0

http://scihub22266oqcxt.onion/10.1186/s12890-020-01388-0
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33407281!7787399!33407281
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suck abstract from ncbi


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pmid33407281      BMC+Pulm+Med 2021 ; 21 (1): 11
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  • Anti-synthetase syndrome: a rare and challenging diagnosis for bilateral ground-glass opacities-a case report with literature review #MMPMID33407281
  • Alfraji N; Mazahir U; Chaudhri M; Miskoff J
  • BMC Pulm Med 2021[Jan]; 21 (1): 11 PMID33407281show ga
  • BACKGROUND: Anti-synthetase syndrome (ASS) is an uncommon immune-mediated entity characterized by myositis, interstitial lung disease (ILD), non-erosive arthritis, and less common features such as fever, Raynaud's phenomenon, and skin changes in association with anti-aminoacyl-transfer-RNA antibodies, most commonly anti-Jo-1 antibodies. CASE PRESENTATION: We present a challenging and rare case of ASS-associated ILD presenting with unexplained respiratory symptoms and bilateral infiltrates on chest imaging during the COVID-19 pandemic. High clinical suspicion for ASS with early appropriate therapy with corticosteroids and immunosuppressive agents led to marked clinical improvement. CONCLUSION: High index of suspicion for ASS is mandated in patients with unexplained ILD. A comprehensive autoimmune work-up is important as an early treatment with corticosteroids with or without immunomodulators improves patient outcomes and survival in an otherwise poor prognostic disease.
  • |*Pandemics[MESH]
  • |*Rare Diseases[MESH]
  • |*SARS-CoV-2[MESH]
  • |Autoantibodies/*immunology[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Middle Aged[MESH]
  • |Myositis/*diagnosis/epidemiology/immunology[MESH]


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