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10.1097/CCO.0000000000000713 http://scihub22266oqcxt.onion/10.1097/CCO.0000000000000713 33405482!7924916!33405482     free     free     free       Curr+Opin+Oncol 2021 ; 33 (2): 149-158 Nephropedia Template TP {{tp|p=33405482|t=2021. Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirus |pdf=|usr=}}{{33405482}} gab.com Text Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirus JO: Curr Opin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=33405482 #FOAvip PURPOSE OF REVIEW: Virtually all viruses have evolved molecular instruments to circumvent cell mechanisms that may hamper their replication, dissemination, or persistence. Among these is p53, a key gatekeeper for cell division and survival that also regulates innate immune responses. This review summarizes the strategies used by different viruses and discusses the mechanisms deployed by SARS-CoV to target p53 activities. RECENT FINDINGS: We propose a typology for the strategies used by different viruses to address p53 functions: hit and run (e.g. IAV, ZIKV), hide and seek (e.g. HIV1), kidnap and exploit (e.g. EBV, HSV1), dominate and suppress (e.g. HR HPV). We discuss the mechanisms by which SARS nsp3 protein targets p53 for degradation and we speculate on the significance for Covid-19 pathogenesis and risk of cancer. SUMMARY: p53 may operate as an intracellular antiviral defense mechanism. To circumvent it, SARS viruses adopt a kidnap and exploit strategy also shared by several viruses with transforming potential. This raises the question of whether SARS infections may make cells permissive to oncogenic DNA damage. Twit Text FOAVip Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirus ????Curr Opin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=33405482 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33405482 #FOAvip English Wikipedia <ref>{{Cite pmid|33405482}}</ref> Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirus #MMPMID33405482 Cardozo CM; Hainaut P Curr Opin Oncol 2021[Mar]; 33 (2): 149-158 PMID33405482show ga PURPOSE OF REVIEW: Virtually all viruses have evolved molecular instruments to circumvent cell mechanisms that may hamper their replication, dissemination, or persistence. Among these is p53, a key gatekeeper for cell division and survival that also regulates innate immune responses. This review summarizes the strategies used by different viruses and discusses the mechanisms deployed by SARS-CoV to target p53 activities. RECENT FINDINGS: We propose a typology for the strategies used by different viruses to address p53 functions: hit and run (e.g. IAV, ZIKV), hide and seek (e.g. HIV1), kidnap and exploit (e.g. EBV, HSV1), dominate and suppress (e.g. HR HPV). We discuss the mechanisms by which SARS nsp3 protein targets p53 for degradation and we speculate on the significance for Covid-19 pathogenesis and risk of cancer. SUMMARY: p53 may operate as an intracellular antiviral defense mechanism. To circumvent it, SARS viruses adopt a kidnap and exploit strategy also shared by several viruses with transforming potential. This raises the question of whether SARS infections may make cells permissive to oncogenic DNA damage. |Animals[MESH] |COVID-19/*virology[MESH] |Humans[MESH] |SARS-CoV-2/*metabolism[MESH]Viral strategies for circumventing p53: the case of severe acute respi(epmc).pdf DeepDyve Pubget Overpricing