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10.3390/ijerph18010284

http://scihub22266oqcxt.onion/10.3390/ijerph18010284
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33401657!7794913!33401657
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suck abstract from ncbi


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pmid33401657      Int+J+Environ+Res+Public+Health 2021 ; 18 (1): ä
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  • The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection #MMPMID33401657
  • Qi J; Zhou Y; Hua J; Zhang L; Bian J; Liu B; Zhao Z; Jin S
  • Int J Environ Res Public Health 2021[Jan]; 18 (1): ä PMID33401657show ga
  • COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs, suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the viral susceptibility of other organs is important for a deeper understanding of viral pathogenesis. Angiotensin-converting enzyme II (ACE2) is the receptor protein of SARS-CoV-2, and TMPRSS2 promotes virus proliferation and transmission. We investigated the ACE2 and TMPRSS2 expression levels of cell types from 31 organs to evaluate the risk of viral infection using single-cell RNA sequencing (scRNA-seq) data. For the first time, we found that the gall bladder and fallopian tube are vulnerable to SARS-CoV-2 infection. Besides, the nose, heart, small intestine, large intestine, esophagus, brain, testis, and kidney are also identified to be high-risk organs with high expression levels of ACE2 and TMPRSS2. Moreover, the susceptible organs are grouped into three risk levels based on the ACE2 and TMPRSS2 expression. As a result, the respiratory system, digestive system, and urinary system are at the top-risk level for SARS-CoV-2 infection. This study provides evidence for SARS-CoV-2 infection in the human nervous system, digestive system, reproductive system, respiratory system, circulatory system, and urinary system using scRNA-seq data, which helps in the clinical diagnosis and treatment of patients.
  • |*Genetic Predisposition to Disease[MESH]
  • |Angiotensin-Converting Enzyme 2/*genetics[MESH]
  • |COVID-19/*genetics[MESH]
  • |Female[MESH]
  • |Gene Expression Profiling[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |RNA, Small Cytoplasmic/*genetics[MESH]
  • |Serine Endopeptidases/*genetics[MESH]


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