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10.1016/j.envint.2020.106361 http://scihub22266oqcxt.onion/10.1016/j.envint.2020.106361 33401173!7832953!33401173     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Environ+Int 2021 ; 147 (ä): 106361 Nephropedia Template TP {{tp|p=33401173|t=2021. A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2 |pdf=|usr=}}{{33401173}} gab.com Text A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2 JO: Environ Int http://www.kidney.de/pget.php?&tw=1&pmid=33401173 #FOAvip Corona virus disease 2019 has spread worldwide, and appropriate drug design and screening activities are required to overcome the associated pandemic. Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S RBD) and human angiotensin converting enzyme 2 (hACE2) was clarified based on interactions between RBD and hesperidin. Interactions between anti-SARS-CoV-2 drugs and therapy were investigated based on the binding energy and druggability of the compounds, and they exhibited negative correlations; the compounds were classified into eight common types of structures with highest activity. An anti-SARS-CoV-2 drug screening strategy based on blocking S RBD/hACE2 binding was established according to the first key change (interactions between hesperidin and S RBD/hACE2) vs the second key change (interactions between anti-SARS-CoV-2 drugs and RBD/hACE2) trends. Our findings provide valuable information on the mechanism of RBD/hACE2 binding and on the associated screening strategies for anti-SARS-CoV-2 drugs based on blocking mechanisms of pockets. Twit Text FOAVip A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2 ????Environ Int http://www.kidney.de/pget.php?&tw=1&pmid=33401173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33401173 #FOAvip English Wikipedia <ref>{{Cite pmid|33401173}}</ref> A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2 #MMPMID33401173 Wang X; Yang C; Sun Y; Sui X; Zhu T; Wang Q; Wang S; Yang J; Yang W; Liu F; Zhang M; Wang Y; Luo Y Environ Int 2021[Feb]; 147 (ä): 106361 PMID33401173show ga Corona virus disease 2019 has spread worldwide, and appropriate drug design and screening activities are required to overcome the associated pandemic. Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S RBD) and human angiotensin converting enzyme 2 (hACE2) was clarified based on interactions between RBD and hesperidin. Interactions between anti-SARS-CoV-2 drugs and therapy were investigated based on the binding energy and druggability of the compounds, and they exhibited negative correlations; the compounds were classified into eight common types of structures with highest activity. An anti-SARS-CoV-2 drug screening strategy based on blocking S RBD/hACE2 binding was established according to the first key change (interactions between hesperidin and S RBD/hACE2) vs the second key change (interactions between anti-SARS-CoV-2 drugs and RBD/hACE2) trends. Our findings provide valuable information on the mechanism of RBD/hACE2 binding and on the associated screening strategies for anti-SARS-CoV-2 drugs based on blocking mechanisms of pockets. |*COVID-19[MESH] |*Pharmaceutical Preparations[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A[MESH] |SARS-CoV-2[MESH]A novel screening strategy of anti-SARS-CoV-2 drugs via blocking inter(epmc).pdf DeepDyve Pubget Overpricing