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10.1016/j.bios.2020.112942 http://scihub22266oqcxt.onion/10.1016/j.bios.2020.112942 33401144!7772087!33401144     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biosens+Bioelectron 2021 ; 176 (ä): 112942 Nephropedia Template TP {{tp|p=33401144|t=2021. Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-kappaB p50 as the regulator of cytokine storm |pdf=|usr=}}{{33401144}} gab.com Text Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-kappaB p50 as the regulator of cytokine storm JO: Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=33401144 #FOAvip 2019 novel coronavirus (2019-nCoV) with strong contagion in the crowd, has ravaged worldwide and severely impacts the human health and epidemic prevention system, by producing a series of significant stress reactions in the body to induce further cytokine storm. Transcription factors (TFs) served as essential DNA binding proteins play an integral role in regulating cytokine storm, and the detection of it in the human coronavirus environment provides especially valuable approaches to diagnosis and treatment of 2019-nCoV and development of antiviral drugs. In this work, an entropy-driven electrochemiluminescence (ECL) biosensor was constructed for ultra-sensitive bioassay of NF-kappaB p50. The strategy primarily capitalizing the splendid double-stranded DNA (dsDNA) binding properties of transcription factors, employing GOAu-Ru composite material as ECL emitter, utilizing entropy-driven reactions for signal amplification method, offered a repeatable proposal for TFs detection. In the absence of TFs, the released DNA1 further went in the entropy-driven reaction, contributing to an "ECL off" state. However, in the presence of TFs, the dsDNA avoided being digested, which blocked DNA1 for participating in the entropy-driven reaction, and the system exhibited an "ECL on" state. Most importantly, the ECL bioanalytical method denoted broad application prospects for NF-kappaB p50 detection with a lower detection limit (9.1 pM). Twit Text FOAVip Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-kappaB p50 as the regulator of cytokine storm ????Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=33401144 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33401144 #FOAvip English Wikipedia <ref>{{Cite pmid|33401144}}</ref> Entropy-driven electrochemiluminescence ultra-sensitive detection strategy of NF-kappaB p50 as the regulator of cytokine storm #MMPMID33401144 Zhang K; Fan Z; Yao B; Zhang T; Ding Y; Zhu S; Xie M Biosens Bioelectron 2021[Mar]; 176 (ä): 112942 PMID33401144show ga 2019 novel coronavirus (2019-nCoV) with strong contagion in the crowd, has ravaged worldwide and severely impacts the human health and epidemic prevention system, by producing a series of significant stress reactions in the body to induce further cytokine storm. Transcription factors (TFs) served as essential DNA binding proteins play an integral role in regulating cytokine storm, and the detection of it in the human coronavirus environment provides especially valuable approaches to diagnosis and treatment of 2019-nCoV and development of antiviral drugs. In this work, an entropy-driven electrochemiluminescence (ECL) biosensor was constructed for ultra-sensitive bioassay of NF-kappaB p50. The strategy primarily capitalizing the splendid double-stranded DNA (dsDNA) binding properties of transcription factors, employing GOAu-Ru composite material as ECL emitter, utilizing entropy-driven reactions for signal amplification method, offered a repeatable proposal for TFs detection. In the absence of TFs, the released DNA1 further went in the entropy-driven reaction, contributing to an "ECL off" state. However, in the presence of TFs, the dsDNA avoided being digested, which blocked DNA1 for participating in the entropy-driven reaction, and the system exhibited an "ECL on" state. Most importantly, the ECL bioanalytical method denoted broad application prospects for NF-kappaB p50 detection with a lower detection limit (9.1 pM). |Biosensing Techniques/*methods/statistics & numerical data[MESH] |COVID-19/complications/*immunology[MESH] |Cytokine Release Syndrome/etiology/*immunology[MESH] |Electrochemical Techniques/methods/statistics & numerical data[MESH] |Entropy[MESH] |Humans[MESH] |Limit of Detection[MESH] |Luminescent Measurements/methods/statistics & numerical data[MESH] |NF-kappa B p50 Subunit/*analysis[MESH] |Pandemics[MESH] |SARS-CoV-2[MESH]Entropy-driven electrochemiluminescence ultra-sensitive detection stra(epmc).pdf DeepDyve Pubget Overpricing