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10.1093/ajcp/aqaa268

http://scihub22266oqcxt.onion/10.1093/ajcp/aqaa268
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33399201!7929413!33399201
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suck abstract from ncbi


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pmid33399201      Am+J+Clin+Pathol 2021 ; 155 (4): 515-521
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  • Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma #MMPMID33399201
  • Balcerek J; Trejo E; Levine K; Couey P; Kornberg ZV; Rogine C; Young C; Li PJ; Shy BR; Taylor JE; Bakhtary S; Friedlander T; Lynch KL; Bern C; Esensten JH
  • Am J Clin Pathol 2021[Mar]; 155 (4): 515-521 PMID33399201show ga
  • OBJECTIVES: Serologic testing for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in potential donors of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) may not be performed until after blood donation. A hospital-based recruitment program for CCP may be an efficient way to identify potential donors prospectively. METHODS: Patients who recovered from known or suspected COVID-19 were identified and recruited through medical record searches and public appeals in March and April 2020. Participants were screened with a modified donor history questionnaire and, if eligible, were asked for consent and tested for SARS-CoV-2 antibodies (IgG and IgM). Participants positive for SARS-CoV-2 IgG were referred for CCP collection. RESULTS: Of 179 patients screened, 128 completed serologic testing and 89 were referred for CCP donation. IgG antibodies to SARS-CoV-2 were detected in 23 of 51 participants with suspected COVID-19 and 66 of 77 participants with self-reported COVID-19 confirmed by polymerase chain reaction (PCR). The anti-SARS-CoV-2 IgG level met the US Food and Drug Administration criteria for "high-titer" CCP in 39% of participants confirmed by PCR, as measured by the Ortho VITROS IgG assay. A wide range of SARS-CoV-2 IgG levels were observed. CONCLUSIONS: A hospital-based CCP donor recruitment program can prospectively identify potential CCP donors. Variability in SARS-CoV-2 IgG levels has implications for the selection of CCP units for transfusion.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/*therapy[MESH]
  • |Female[MESH]
  • |Hospitals[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Linear Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |San Francisco[MESH]
  • |Tissue Donors[MESH]
  • |Tissue and Organ Procurement/*methods/organization & administration[MESH]


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