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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Clin+Pathol 2021 ; 155 (4): 515-521 Nephropedia Template TP
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Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma #MMPMID33399201
Balcerek J; Trejo E; Levine K; Couey P; Kornberg ZV; Rogine C; Young C; Li PJ; Shy BR; Taylor JE; Bakhtary S; Friedlander T; Lynch KL; Bern C; Esensten JH
Am J Clin Pathol 2021[Mar]; 155 (4): 515-521 PMID33399201show ga
OBJECTIVES: Serologic testing for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in potential donors of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) may not be performed until after blood donation. A hospital-based recruitment program for CCP may be an efficient way to identify potential donors prospectively. METHODS: Patients who recovered from known or suspected COVID-19 were identified and recruited through medical record searches and public appeals in March and April 2020. Participants were screened with a modified donor history questionnaire and, if eligible, were asked for consent and tested for SARS-CoV-2 antibodies (IgG and IgM). Participants positive for SARS-CoV-2 IgG were referred for CCP collection. RESULTS: Of 179 patients screened, 128 completed serologic testing and 89 were referred for CCP donation. IgG antibodies to SARS-CoV-2 were detected in 23 of 51 participants with suspected COVID-19 and 66 of 77 participants with self-reported COVID-19 confirmed by polymerase chain reaction (PCR). The anti-SARS-CoV-2 IgG level met the US Food and Drug Administration criteria for "high-titer" CCP in 39% of participants confirmed by PCR, as measured by the Ortho VITROS IgG assay. A wide range of SARS-CoV-2 IgG levels were observed. CONCLUSIONS: A hospital-based CCP donor recruitment program can prospectively identify potential CCP donors. Variability in SARS-CoV-2 IgG levels has implications for the selection of CCP units for transfusion.
|Adolescent[MESH]
|Adult[MESH]
|Aged[MESH]
|Aged, 80 and over[MESH]
|COVID-19 Serological Testing/*methods[MESH]
|COVID-19 Serotherapy[MESH]
|COVID-19/*therapy[MESH]
|Female[MESH]
|Hospitals[MESH]
|Humans[MESH]
|Immunization, Passive[MESH]
|Linear Models[MESH]
|Male[MESH]
|Middle Aged[MESH]
|San Francisco[MESH]
|Tissue Donors[MESH]
|Tissue and Organ Procurement/*methods/organization & administration[MESH]