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10.1007/s12272-020-01299-y

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suck abstract from ncbi


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pmid33398691      Arch+Pharm+Res 2021 ; 44 (1): 84-98
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  • Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm #MMPMID33398691
  • Lee CH
  • Arch Pharm Res 2021[Jan]; 44 (1): 84-98 PMID33398691show ga
  • Unexpected viral infections outbreaks, significantly affect human health, leading to increased mortality and life disruption. Among them is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged as a deadly pandemic, calling for intense research efforts on its pathogenicity mechanism and development of therapeutic strategies. In the SARS-CoV-2 cytokine storm, systemic inflammation has been associated with severe illness and mortality. Recent studies have demonstrated special pro-resolving lipids mediators (SPMs) lipoxins, resolvins, maresins, and protectins as potential therapeutic options for abnormal viral-triggered inflammation. Pro-resolving lipids mediators have shown great promise for the treatment of Herpes simplex virus, respiratory syncytial virus, human immunodeficiency virus, and hepatitis C virus. Based on this, studies are being conducted on their therapeutic effects in SARS-CoV-2 infection. In this review, we discussed SPMs and reviewed evidence from recent studies on SPMs as therapeutic options for viral infections, including SARS-CoV2. Based on our analysis of the previous study, we argue that SPMs are a potential treatment for SARS-CoV-2 infection and other viral infections. We expect further research on how SPMs modulate viral-triggered inflammation through G-protein-coupled receptors (GPCRs), and chemical stability and druggability of SPMs.
  • |*COVID-19 Drug Treatment[MESH]
  • |Animals[MESH]
  • |COVID-19/*metabolism[MESH]
  • |Cytokine Release Syndrome/*drug therapy/*metabolism[MESH]
  • |Fatty Acids, Unsaturated/administration & dosage/metabolism[MESH]
  • |Humans[MESH]
  • |Lipoxins/administration & dosage/*metabolism[MESH]


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