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10.21203/rs.3.rs-128348/v1

http://scihub22266oqcxt.onion/10.21203/rs.3.rs-128348/v1
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33398261!7781325!33398261
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suck abstract from ncbi


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pmid33398261      Res+Sq 2020 ; ä (ä): ä
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  • Broad Auto-Reactive IgM Responses Are Common In Critically Ill COVID-19 Patients #MMPMID33398261
  • Maier C; Wong A; Woodhouse I; Schneider F; Kulpa D; Silvestri G
  • Res Sq 2020[Dec]; ä (ä): ä PMID33398261show ga
  • The pathogenesis of severe COVID-19 remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonstrate that plasma from a high proportion (77%) of critically ill COVID-19 patients, but not healthy controls, contains broadly auto-reactive immunoglobulin M (IgM), and only infrequently auto-reactive IgG or IgA. Importantly, these auto-IgM preferentially recognize primary human lung cells in vitro, including pulmonary endothelial and epithelial cells. By using a combination of flow cytometry, LDH-release assays, and analytical proteome microarray technology, we identified high-affinity, complement-fixing, auto-reactive IgM directed against 263 candidate auto-antigens, including numerous molecules preferentially expressed on cellular membranes in pulmonary, vascular, gastrointestinal, and renal tissues. These findings suggest that broad IgM-mediated autoimmune reactivity may be involved in the pathogenesis of severe COVID-19, thereby identifying a potential target for novel therapeutic interventions.
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