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10.1038/s41541-020-00264-6 http://scihub22266oqcxt.onion/10.1038/s41541-020-00264-6 33398006!7782831!33398006     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       NPJ+Vaccines 2021 ; 6 (1): 2 Nephropedia Template TP {{tp|p=33398006|t=2021. SARS-CoV-2 structural features may explain limited neutralizing-antibody responses |pdf=|usr=}}{{33398006}} gab.com Text SARS-CoV-2 structural features may explain limited neutralizing-antibody responses JO: NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33398006 #FOAvip Neutralizing antibody responses of SARS-CoV-2-infected patients may be low and of short duration. We propose here that coronaviruses employ a structural strategy to avoid strong and enduring antibody responses. Other viruses induce optimal and long-lived neutralizing antibody responses, thanks to 20 or more repetitive, rigid antigenic epitopes, spaced by 5-10 nm, present on the viral surface. Such arrays of repetitive and highly organized structures are recognized by the immune system as pathogen-associated structural patterns (PASPs), which are characteristic for pathogen surfaces. In contrast, coronaviruses are large particles with long spikes (S protein) embedded in a fluid membrane. Therefore, the neutralizing epitopes (which are on the S protein) are loosely "floating" and widely spaced by an average of about 25 nm. Consequently, recruitment of complement is poor and stimulation of B cells remains suboptimal, offering an explanation for the inefficient and short-lived neutralizing antibody responses. Twit Text FOAVip SARS-CoV-2 structural features may explain limited neutralizing-antibody responses ????NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33398006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33398006 #FOAvip English Wikipedia <ref>{{Cite pmid|33398006}}</ref> SARS-CoV-2 structural features may explain limited neutralizing-antibody responses #MMPMID33398006 Bachmann MF; Mohsen MO; Zha L; Vogel M; Speiser DE NPJ Vaccines 2021[Jan]; 6 (1): 2 PMID33398006show ga Neutralizing antibody responses of SARS-CoV-2-infected patients may be low and of short duration. We propose here that coronaviruses employ a structural strategy to avoid strong and enduring antibody responses. Other viruses induce optimal and long-lived neutralizing antibody responses, thanks to 20 or more repetitive, rigid antigenic epitopes, spaced by 5-10 nm, present on the viral surface. Such arrays of repetitive and highly organized structures are recognized by the immune system as pathogen-associated structural patterns (PASPs), which are characteristic for pathogen surfaces. In contrast, coronaviruses are large particles with long spikes (S protein) embedded in a fluid membrane. Therefore, the neutralizing epitopes (which are on the S protein) are loosely "floating" and widely spaced by an average of about 25 nm. Consequently, recruitment of complement is poor and stimulation of B cells remains suboptimal, offering an explanation for the inefficient and short-lived neutralizing antibody responses. äSARS-CoV-2 structural features may explain limited neutralizing-antibo(epmc).pdf DeepDyve Pubget Overpricing