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10.1038/s41467-020-20323-9 http://scihub22266oqcxt.onion/10.1038/s41467-020-20323-9 33397975!7782551!33397975     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33397975&cmd=llinks): Failed to open stream: HTTP request failed! 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The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 |pdf=|usr=}}{{33397975}} gab.com Text The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33397975 #FOAvip Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we interrogate the transcriptional features and cellular landscape of the aging human lung. By intersecting these age-associated changes with experimental data on SARS-CoV-2, we identify several factors that may contribute to the heightened severity of COVID-19 in older populations. The aging lung is transcriptionally characterized by increased cell adhesion and stress responses, with reduced mitochondria and cellular replication. Deconvolution analysis reveals that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decrease with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21(+) dendritic cells increase with age. Several age-associated genes directly interact with the SARS-CoV-2 proteome. Age-associated genes are also dysregulated by SARS-CoV-2 infection in vitro and in patients with severe COVID-19. These analyses illuminate avenues for further studies on the relationship between age and COVID-19. Twit Text FOAVip The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33397975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33397975 #FOAvip English Wikipedia <ref>{{Cite pmid|33397975}}</ref> The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 #MMPMID33397975 Chow RD; Majety M; Chen S Nat Commun 2021[Jan]; 12 (1): 4 PMID33397975show ga Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we interrogate the transcriptional features and cellular landscape of the aging human lung. By intersecting these age-associated changes with experimental data on SARS-CoV-2, we identify several factors that may contribute to the heightened severity of COVID-19 in older populations. The aging lung is transcriptionally characterized by increased cell adhesion and stress responses, with reduced mitochondria and cellular replication. Deconvolution analysis reveals that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decrease with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21(+) dendritic cells increase with age. Several age-associated genes directly interact with the SARS-CoV-2 proteome. Age-associated genes are also dysregulated by SARS-CoV-2 infection in vitro and in patients with severe COVID-19. These analyses illuminate avenues for further studies on the relationship between age and COVID-19. |A549 Cells[MESH] |Adult[MESH] |Aged[MESH] |Aging/*genetics/metabolism/pathology[MESH] |COVID-19/*genetics/metabolism/pathology/virology[MESH] |Endothelial Cells/pathology[MESH] |Female[MESH] |Fibroblasts/pathology[MESH] |Gene Expression[MESH] |Humans[MESH] |Lung/metabolism/pathology/*physiology/virology[MESH] |Male[MESH] |Middle Aged[MESH] |Pericytes/pathology[MESH] |RNA-Seq[MESH] |SARS-CoV-2/isolation & purification[MESH] |Transcriptome[MESH]The aging transcriptome and cellular landscape of the human lung in re(epmc).pdf DeepDyve Pubget Overpricing