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10.1038/s41467-020-20095-2 http://scihub22266oqcxt.onion/10.1038/s41467-020-20095-2 33397903!7782488!33397903     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33397903&cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray |pdf=|usr=}}{{33397903}} gab.com Text Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33397903 #FOAvip The current practice for diagnosis of COVID-19, based on SARS-CoV-2 PCR testing of pharyngeal or respiratory specimens in a symptomatic patient at high epidemiologic risk, likely underestimates the true prevalence of infection. Serologic methods can more accurately estimate the disease burden by detecting infections missed by the limited testing performed to date. Here, we describe the validation of a coronavirus antigen microarray containing immunologically significant antigens from SARS-CoV-2, in addition to SARS-CoV, MERS-CoV, common human coronavirus strains, and other common respiratory viruses. A comparison of antibody profiles detected on the array from control sera collected prior to the SARS-CoV-2 pandemic versus convalescent blood specimens from virologically confirmed COVID-19 cases demonstrates near complete discrimination of these two groups, with improved performance from use of antigen combinations that include both spike protein and nucleoprotein. This array can be used as a diagnostic tool, as an epidemiologic tool to more accurately estimate the disease burden of COVID-19, and as a research tool to correlate antibody responses with clinical outcomes. Twit Text FOAVip Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33397903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33397903 #FOAvip English Wikipedia <ref>{{Cite pmid|33397903}}</ref> Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray #MMPMID33397903 de Assis RR; Jain A; Nakajima R; Jasinskas A; Felgner J; Obiero JM; Norris PJ; Stone M; Simmons G; Bagri A; Irsch J; Schreiber M; Buser A; Holbro A; Battegay M; Hosimer P; Noesen C; Adenaiye O; Tai S; Hong F; Milton DK; Davies DH; Contestable P; Corash LM; Busch MP; Felgner PL; Khan S Nat Commun 2021[Jan]; 12 (1): 6 PMID33397903show ga The current practice for diagnosis of COVID-19, based on SARS-CoV-2 PCR testing of pharyngeal or respiratory specimens in a symptomatic patient at high epidemiologic risk, likely underestimates the true prevalence of infection. Serologic methods can more accurately estimate the disease burden by detecting infections missed by the limited testing performed to date. Here, we describe the validation of a coronavirus antigen microarray containing immunologically significant antigens from SARS-CoV-2, in addition to SARS-CoV, MERS-CoV, common human coronavirus strains, and other common respiratory viruses. A comparison of antibody profiles detected on the array from control sera collected prior to the SARS-CoV-2 pandemic versus convalescent blood specimens from virologically confirmed COVID-19 cases demonstrates near complete discrimination of these two groups, with improved performance from use of antigen combinations that include both spike protein and nucleoprotein. This array can be used as a diagnostic tool, as an epidemiologic tool to more accurately estimate the disease burden of COVID-19, and as a research tool to correlate antibody responses with clinical outcomes. |Antibodies, Viral/*blood/immunology[MESH] |Antigens, Viral/*blood/immunology[MESH] |COVID-19 Testing[MESH] |COVID-19/blood/diagnosis/*immunology[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology[MESH] |Immunoglobulin M/blood/immunology[MESH] |Microarray Analysis/methods[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology[MESH] |Neutralization Tests[MESH] |SARS-CoV-2/*immunology[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH]Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using(epmc).pdf DeepDyve Pubget Overpricing